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Damnacanthal

p56lck tyrosine kinase inhibitor
 
BML-EI274-0001 1 mg 250.00 USD
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Replaces Prod. #: ALX-270-181

Damnacanthal is a potent and selective inhibitor of p56lck tyrosine kinase. It inhibits p56lck autophosphorylation (IC50=17 nM) as well as phosphorylation of exogenous substrates (IC50=620 nM) in cell-free assays. Damnacanthal shows a 10-fold selectivity for p56lck over PKA and PKC and 40-fold selectivity over four receptor tyrosine kinases as well as 7–20-fold selectivity over the homologous enzymes p60src and p59fyn.

Product Specification

Alternative Name:3-Hydroxy-1-methoxyanthraquinone-2-aldehyde
 
Formula:C16H10O5
 
MW:282.2
 
CAS:477-84-9
 
Purity:≥95% (HPLC)
 
Identity:Determinedy by NMR.
 
Appearance:Pale orange solid.
 
Solubility:Soluble in DMSO.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Protect from light.
 
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Product Literature References

Damnacanthal is a highly potent, selective inhibitor of p56lck tyrosine kinase activity: C.R. Faltynek, et al.; Biochemistry 34, 12404 (1995), Abstract;
Induction of normal phenotypes in ras-transformed cells by damnacanthal from Morinda citrifolia: T. Hiramatsu, et al.; Cancer Lett. 73, 161 (1993), Abstract;
Effects of three compounds extracted from Morinda lucida on Plasmodium falciparum: K. Koumaglo, et al.; Planta Med. 58, 533 (1992), Abstract;
Anthraquinone and anthrone series—XXIII: The non-identity of 1:3:8-trihydroxy-2-hydroxymethyl-anthraquinone with versicolorin and a synthesis of damnacanthol and damnacanthal: N.R. Ayyangar, et al.; Tetrahedron 6, 331 (1959),
Chemistry of Damnacanthus Genus. I - The Anthraquinone Coloring Matter from Damnacanthus major, D. major var. parvifolius, and D. indicus var. microphyllus. (1): S. Nonomura; Yakugaku Zasshi 75, 219 (1955), (Article in Japanese), Abstract;

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