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Gö 6976

PKC inhibitor
 
BML-EI269-0500 500 µg 236.00 USD
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Replaces Prod. #: ALX-270-021

Very potent protein kinase C (PKC) inhibitor with high selectivity for the PKC isotypes α and β. Inhibits PKCα (IC50=2.3nM) and PKCß1 (IC50=6.2nM) but has no effect on δ, ε or γ isotypes. Potent antagonist of HIV-1 induction.

Product Specification

Alternative Name:12-(2-Cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole
 
Formula:C24H18N4O
 
MW:378.4
 
CAS:136194-77-9
 
Purity:≥95% (HPLC, TLC)
 
Appearance:Off-white to yellow solid.
 
Solubility:Soluble in DMSO (25mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stock solutions are stable for at least 3-4 months when  stored at -20°C.
 
Handling:Protect from light.
 
270-021
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270-021

Product Literature References

Pathobiology of renal-specific oxidoreductase/myo-inositol oxygenase in diabetic nephropathy: its implications in tubulointerstitial fibrosis: P. Xie, et al.; Am. J. Physiol. Renal Physiol. 298, F1393 (2010), Abstract; Full Text
Atypical isoforms of pKc and insulin secretion from pancreatic beta- cells: evidence using Go 6976 and Ro 31-8220 as Pkc inhibitors: T.E. Harris, et al.; BBRC 227, 672 (1996), Abstract;
Inhibition of protein kinase C mu by various inhibitors. Differentiation from protein kinase c isoenzymes: M. Gschwendt, et al.; FEBS Lett. 392, 77 (1996), Abstract;
N-protein kinase C isoenzymes may be involved in the regulation of various neutrophil functions: K. Wenzel-Seifert, et al.; BBRC 200, 1536 (1994), Abstract;
Go 6976, a selective inhibitor of protein kinase C, is a potent antagonist of human immunodeficiency virus 1 induction from latent/low- level-producing reservoir cells in vitro: K.O. Qatsha, et al.; PNAS 90, 4674 (1993), Abstract;
Non-glycosidic/non-aminoalkyl-substituted indolocarbazoles as inhibitors of protein kinase C: J. Kleinschroth, et al.; Bioorg. Med. Chem. Lett. 3, 1959 (1993),
Selective inhibition of protein kinase C isozymes by the indolocarbazole Go 6976: G. Martiny-Baron, et al.; J. Biol. Chem. 268, 9194 (1993), Abstract; Full Text

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