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AG-126

Inhibits tyrosine kinase-dependent B cell receptor signaling
 
BML-EI263-0005 5 mg 90.00 USD
 
BML-EI263-0025 25 mg 358.00 USD
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Replaces Prod. #: ALX-270-031

AG-126 prevents lipopolysaccharide-induced lethal toxicity (septic shock) in mice. Administered at 1.5 mg/mouse, it reduced LPS-induced lethal toxicity from 95% to 10%. AG-126 greatly reduces LPS-induced tyrosine phosphorylation of p42MAPK in murine peritoneal macrophages at 50 µM. EGFR, Her-2/neu receptor or PDGF-R are not inhibited at 100 µM. Inhibits tyrosine kinase-dependent B cell receptor signaling.

Product Specification

Alternative Name:3-Hydroxy-4-nitrobenzylidenemalononitrile
 
Formula:C10H5N3O3
 
MW:215.2
 
CAS:118409-62-4
 
Purity:≥98% (HPLC)
 
Appearance:Yellow solid.
 
MeltingPoint:181-182°C
 
Solubility:Soluble in DMSO (25mg/ml) or 100% ethanol (5mg/ml warm).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Handling:Store tightly sealed in the dark. Protect from light.
 
BML-EI263 structure
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BML-EI263 structure

Product Literature References

Stage-Specific Expression of TNF╬▒ Regulates Bad/Bid-Mediated Apoptosis and RIP1/ROS-Mediated Secondary Necrosis in Birnavirus-Infected Fish Cells: W. Wang, et al.; PLoS One 6, e16740 (2011), Abstract; Full Text
The tyrosine kinase inhibitor tyrphostin AG 126 reduces the multiple organ failure induced by zymosan in the rat: L. Dugo, et al.; Intensive Care Med. 28, 775 (2002), Abstract;
The Tyrosine Kinase Inhibitor Tyrphostin AG 126 Reduces the Development of Colitis in the Rat: S. Cuzzocrea, et al.; Lab. Invest. 80, 1439 (2000), Abstract; Full Text
The Tyrosine Kinase Inhibitor Tyrphostin AG126 Reduces the Development of Acute and Chronic Inflammation: S. Cuzzocrea, et al.; Am. J. Pathol. 157, 145 (2000), Abstract; Full Text
Tyrosine kinase inhibition: an approach to drug development: A. Levitzki & A. Gazit; Science 267, 1782 (1995), Abstract;
Prevention of lipopolysaccharide-induced lethal toxicity by tyrosine kinase inhibitors: A. Novogrodsky, et al.; Science 264, 1319 (1994), Abstract;
Protein-tyrosine kinase activity tightly associated with human type II Fc gamma receptors: G. Sarmay, et al.; PNAS 91, 4140 (1994), Abstract;
Receptor-mediated activation of human B lymphocytes in a nonphosphotyrosine-dependent manner: C.M. Roifman & G. Wang; J. Immunol. 149, 1179 (1992), Abstract;
Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors: A. Gazit, et al.; J. Med. Chem. 32, 2344 (1989), Abstract;

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