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1-Aminobenzotriazole

Cytochrome P450 inhibitor
 
BML-EI259-0100 100 mg 128.00 USD
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Suicide substrate for cytochrome P-450. Inhibits oxidative drug metabolism in vivo. Blocks ω-oxidation of arachidonic acid but not epoxidation.

Product Specification

Formula:C6H6N4
 
MW:134.1
 
CAS:1614-12-6
 
Purity:≥99% (GC)
 
Appearance:White solid.
 
Solubility:Soluble in water.
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
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Product Literature References

1-Aminobenzotriazole-induced destruction of hepatic and renal cytochromes P450 in male Sprague-Dawley rats: C. A. Mugford, et al.; Fundam. Appl. Toxicol. 19, 43 (1992), Abstract;
In vivo inhibition of oxidative drug metabolism by, and acute toxicity of, 1-aminobenzotriazole (ABT). A tool for biochemical toxicology: B. A. Mico, et al.; Biochem. Toxicol. 37, 2515 (1988), Abstract;
Inactivation of rabbit pulmonary cytochrome P-450 in microsomes and isolated perfused lungs by the suicide substrate 1-aminobenzotriazole: J. M. Mathews, et al.; J. Pharmacol. Exp. Ther. 235, 186 (1985), Abstract;

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