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AG-879

NGF receptor inhibitor
 
BML-EI258-0005 5 mg 89.00 USD
 
BML-EI258-0025 25 mg 362.00 USD
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Replaces Prod. #: ALX-270-138

AG-879, a member of the tyrphostin family of tyrosine kinase inhibitors, inhibits NGF receptor (pp140c-trk) autophosphorylation selectively with no inhibition of EGF or PDGF receptor phosphorylation (IC50=10 µM). AG-879 inhibits NGF-induced neurite outgrowth in PC12 cells.

Product Specification

Formula:C18H24N2OS
 
MW:316.5
 
CAS:148741-30-4
 
Purity:≥99% (HPLC)
 
Appearance:Yellow solid.
 
MeltingPoint:223-224°C
 
Solubility:Soluble in 100% ethanol (25mg/ml) or DMSO (25mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
 
Handling:Protect from light.
 
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Product Literature References

The tyrosine kinase inhibitor tyrphostin blocks the cellular actions of nerve growth factor: M. Ohmichi, et al.; Biochemistry 32, 4650 (1993), Abstract;

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