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Tyrphostin 46

Tyrosine kinase inhibitor
 
BML-EI257-0050 50 mg 218.00 USD
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Replaces Prod. #: ALX-270-131

Inhibits EGF receptor kinase (IC50=9.2 µM), p56lck (IC50=22 µM) and PDGF (IC50=50 µM) receptor kinase.

Product Specification

Alternative Name:3,4-Dihydroxycyanocinnamide
 
Formula:C10H8N2O3
 
MW:204.2
 
CAS:122520-85-8
 
Purity:≥98% (TLC)
 
Appearance:Brown solid.
 
MeltingPoint:230-231°C
 
Solubility:Soluble in DMSO (>25mg/ml) or 100% ethanol (5mg/ml warm).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Handling:Store tightly sealed and protect from light. Make solutions fresh daily.
 
bml-ei257
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Product Literature References

Bicyclic compounds as ring-constrained inhibitors of protein-tyrosine kinase p56lck: T.R. Burke Jr., et al.; J. Med. Chem. 36, 425 (1993), Abstract;
T.R. Burke Jr., et al.; 204th National ACS Meeting Conference Proceedings (1992),
Tyrphostins as molecular tools and potential antiproliferative drugs: A. Levitzki & C. Gilon; Trends Pharmacol. Sci. 12, 171 (1991), Abstract;
Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors: A. Gazit, et al.; J. Med. Chem. 32, 2344 (1989), Abstract;

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For Research Use Only. Not for use in diagnostic procedures.
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