Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

RG-13022

Tyrosine kinase inhibitor
 
BML-EI252-0005 5 mg Inquire for pricing
Do you need bulk/larger quantities?
 
Replaces Prod. #: ALX-270-148

RG-13022 is a non-phenolic tyrphostin analog, which inhibits the EGF receptor (IC50=5 µM) and PDGF receptor tyrosine kinases, and is long-acting. It inhibits EGF-stimulated HER14 cell proliferation (IC50=1 µM) as well as tumor growth in vivo. It inhibits both EGF- and PDGF-stimulated DNA synthesis in human glioma cell lines. RG-13022 is non-phenolic and therefore possesses less antioxidant activity than other tyrphostins.

Product Specification

Alternative Name:3,4-Dimethoxy-α-(3-pyridyl)-(Z)-cinnamonitrile
 
Formula:C16H14N2O2
 
MW:266.3
 
CAS:136831-48-6
 
Purity:≥98% (TLC)
 
Appearance:White solid.
 
Solubility:Soluble at 25mg/ml in DMSO or 100% ethanol.
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Store, as supplied, at room temperature for up to 2 years. Store solutions at -20°C for up to 3 months.
 
Handling:Store tightly sealed in the dark. Protect from light.
 
bml-ei252
Please mouse over
bml-ei252

Product Literature References

Inhibitors of protein tyrosine phosphorylation reduce the proliferation of two human glioma cell lines: P.A. Oude Weernink, et al.; Neurosurgery 38, 108 (1996), Abstract;
The antiproliferative effects of tyrosine kinase inhibitors tyrphostins on a human squamous cell carcinoma in vitro and in nude mice: T. Yoneda, et al.; Cancer Res. 51, 4430 (1991), Abstract;

Recommend this page

 
For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2017 Enzo Life Sciences, Inc.,