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Troleandomycin

Cytochrome P450 inhibitor
 
BML-EI249-0010 10 mg 93.00 USD
 
BML-EI249-0050 50 mg 393.00 USD
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Macrolide antibiotic. Troleandomycin inhibits cytochrome P-450 mediated NO release from NG-hydroxy-L-arginine (92% inhibition at 20 µM).

Product Specification

Formula:C41H67NO15
 
MW:814
 
CAS:2751-09-9
 
Purity:≥98% (TLC)
 
Appearance:White solid.
 
Solubility:Soluble in DMSO (50mg/ml) or ethanol (25mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Store, as supplied, at room temperature for up to 5 years. Store solutions at -20°C for up to 3 months.
 
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Product Literature References

Hydroxylation of 20-hydroxyvitamin D3 by human CYP3A4: C.Y. Cheng, et al.; J. Steroid. Biochem. Mol. Biol. 159, 131 (2016), Application(s): Cell culture, Abstract;
P450-Based Drug-Drug Interactions of Amiodarone and its Metabolites: Diversity of Inhibitory Mechanisms: M.G. McDonald, et al. ; Drug Metab. Dispos. 43, 1661 (2015), Application(s): Chemical inhibition assay, Abstract; Full Text
Cytochrome P450 catalyzes the oxidation of N omega-hydroxy-L-arginine by NADPH and O2 to nitric oxide and citrulline: J.-L Boucher et al.; BBRC 187, 880 (1992), Abstract;

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For Research Use Only. Not for use in diagnostic procedures.
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