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Hydroxy-2-naphthalenylmethylphosphonic acid

Insulin receptor inhibitor
 
BML-EI247-0005 5 mg 70.00 USD
 
BML-EI247-0025 25 mg 290.00 USD
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HNMPA is a membrane impermeable inhibitor of insulin receptor tyrosine kinase (IC50 = 100µM); in rat adipocytes (IC50 = 10µM). Inhibits serine and tyrosine autophosphorylation by the human insulin receptor.

Product Specification

Formula:C11H11O4P
 
MW:238.2
 
CAS:132541-52-7
 
Purity:≥98% (TLC)
 
Appearance:White solid.
 
MeltingPoint:≥250°C dec.
 
Solubility:Soluble in 100% ethanol (25mg/ml), DMSO (25ml/ml) or 5% Sodium bicarbonate (25mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
 
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Product Literature References

Catalysis of serine and tyrosine autophosphorylation by the human insulin receptor: K. Baltensperger; Proc. Natl. Acad. Sci. USA 89, 7885 (1992), Abstract;
Design of a selective insulin receptor tyrosine kinase inhibitor and its effect on glucose uptake and metabolism in intact cells: R. Saperstein et al.; Biochemistry 28, 5694 (1989), Abstract;

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