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5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole

Casein kinase inhibitor
 
BML-EI231-0050 50 mg 153.00 USD
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Replaces Prod. #: ALX-270-095

DRB is a potent and specific inhibitor of casein kinase II (CKII, IC50~6 µM). It has been used to inhibit RNA polymerase II mediated-transcription which may be dependent on CKII and its interaction with ATF-1.

Product Specification

Alternative Name:DRB, 5,6-Dichlorobenzimidazole riboside
 
Formula:C12H12Cl2N2O4
 
MW:319.1
 
CAS:53-85-0
 
Purity:≥97% (TLC)
 
Identity:Determined by 1H-NMR.
 
Appearance:White solid.
 
Solubility:Soluble in DMSO (20mg/ml), 100% ethanol, and dimethyl formamide (100mM).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
 
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Product Literature References

Increased 14-3-3 phosphorylation observed in Parkinson's disease reduces neuroprotective potential of 14-3-3 proteins: S.R. Slone, et al.; Neurobiol. Dis. 79, 1 (2015), Application(s): Cell Culture, Abstract;
Histone hyperacetylation during SV40 transcription is regulated by p300 and RNA polymerase II translocation: L. Balakrishnan & B. Milavetz; J. Mol Biol. 371, 1022 (2007), Abstract; Full Text
RNA synthesis block by 5, 6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) triggers p53-dependent apoptosis in human colon carcinoma cells: R.H. te Poele, et al.; Oncogene 18, 5765 (1999), Abstract; Full Text
Copurification of casein kinase II with transcription factor ATF/E4TF3: T. Wada, et al.; Nucleic Acids Res. 24, 876 (1996), Abstract;
Inhibition of germinal vesicle breakdown in bovine oocytes by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB): C.E. Farin & L. Yang; Mol. Reprod. Dev. 37, 284 (1994), Abstract;
Kinetics of inhibition by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole on calf thymus casein kinase II: R.O. Zandomeni; Biochem. J. 262, 469 (1989), Abstract;
Casein kinase type II is involved in the inhibition by 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole of specific RNA polymerase II transcription: R. Zandomeni, et al.; J. Biol. Chem. 261, 3414 (1986), Abstract;
Mechanism of action of 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole. II. A resistant human cell mutant with an altered transcriptional machinery: B. Mittleman, et al.; J. Mol. Biol. 165, 461 (1983), Abstract;
Mechanism of action of DRB. III. Effect on specific in vitro initiation of transcription: R. Zandomeni, et al. ; J. Mol. Biol. 167, 561 (1983), Abstract;
Halobenzimidazole ribosides and RNA synthesis of cells and viruses: I. Tamm & P.B. Sehgal; Adv. Virus Res. 22, 187 (1978), Abstract;

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