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KN-62

CaM kinase inhibitor
 
BML-EI230-0001 1 mg 141.00 USD
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Replaces Prod. #: ALX-430-024

KN-62 is a potent and selective inhibitor of Ca2+/calmodulin kinase II (Ki=0.9 µM). Causes cells to arrest in S phase. In HEK-293 cells expressing type III adenylyl cyclase (III-AC), 10 µM blocked CaMKII phosphorylation of III-AC and inhibited hormone-stimulated Ca2+ oscillations.

Product Specification

Formula:C38H35N5O6S2
 
MW:721.8
 
CAS:127191-97-3
 
Purity:≥98% (TLC)
 
Identity:Determined by 1H-NMR and MS.
 
Appearance:White to yellow solid.
 
Solubility:Soluble in methanol and DMSO (50mg/ml)
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
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Product Literature References

Phosphorylation and inhibition of type III adenylyl cyclase by calmodulin-dependent protein kinase II in vivo: J. Wei et al.; J. Biol. Chem. 271, 24231 (1996), Abstract;
Protection by naringin and some other flavonoids of hepatocytic autophagy and endocytosis against inhibition by okadaic acid: P.B. Gordon, et al.; J. Biol. Chem. 270, 5830 (1995), Abstract; Full Text
The effect of KN-62, Ca2+/calmodulin dependent protein kinase II inhibitor on cell cycle: H. Minami et al.; Biochem. Biophys. Res. Commun. 199, 241 (1994), Abstract;
Inhibition of insulin secretion by KN-62, a specific inhibitor of the multifunctional Ca2+/calmodulin-dependent protein kinase II: R.M. Wenham et al.; Biochem. Biophys. Res. Commun. 189, 128 (1992), Abstract;
A selective Ca2+/calmodulin-dependent protein kinase II inhibitor, KN-62, inhibits the enhanced phosphorylation and the activation of tyrosine hydroxylase by 56 mM K+ in rat pheochromocytoma PC12h cells: A. Ishii et al.; Biochem. Biophys. Res. Commun. 176, 1051 (1991), Abstract;
Effects of KN-62, a specific inhibitor of calcium/calmodulin-dependent protein kinase II, on long-term potentiation in the rat hippocampus: I. Ito et al.; Neurosci. Lett. 121, 119 (1991), Abstract;
Inhibitory effects of KN-62, a specific inhibitor of Ca/calmodulin-dependent protein kinase II, on serotonin-evoked C1-current and 36-C1-efflux in Xenopus oocytes: M. Tohda et al.; Neurosci. Lett. 129, 47 (1991), Abstract;
KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazi ne, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II: H. Tokumitsu et al.; J. Biol. Chem. 265, 4315 (1990), Abstract;

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