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AG-370

PDGF receptor inhibitor
 
BML-EI229-0002 2 mg 111.00 USD
 
BML-EI229-0010 10 mg 422.00 USD
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Replaces Prod. #: ALX-270-139

Member of the tyrphostin family of tyrosine kinase inhibitors. Selective inhibitor of the PDGF receptor kinase (IC50=20µM) vs. the EGF receptor kinase (IC50=820µM). Inhibits PDGF-induced mitogenesis in human bone marrow fibroblasts.

Product Specification

Alternative Name:Tyrphostin AG 370, Tyrphostin B7, 2-Amino-4-(1H-indol-5-yl)-1,1,3-tricyanobuta-1,3-diene
 
Formula:C15H9N5
 
MW:287.3
 
CAS:134036-53-6
 
Purity:≥99% (TLC)
 
Appearance:Yellow solid.
 
MeltingPoint:300-302°C
 
Solubility:Soluble in DMSO (25mg/ml) or 100% ethanol (2mg/ml, warm).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months at -20°C.
 
Handling:Store tightly sealed in the dark. Protect from light.
 
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Product Literature References

Inhibition of platelet-derived growth factor-induced mitogenesis and tyrosine kinase activity in cultured bone marrow fibroblasts by tyrphostins: M.C. Bryckaert, et al.; Exp. Cell Res. 199, 255 (1992), Abstract;
Inhibition of protein-tyrosine kinases by tyrphostins: A. Levitzki, et al.; Methods Enzymol. 201, 347 (1991), Abstract;

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