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Chelerythrine chloride

PKC inhibitor
 
BML-EI225-0005 5 mg 89.00 USD
 
BML-EI225-0025 25 mg 372.00 USD
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Replaces Prod. #: ALX-350-008

Reported to be a potent and selective inhibitor of protein kinase C (IC50=0.66µM). Although chelerythrine has numerous documented biological effects, studies have raised serious doubts about the effectiveness of chelerythrine as a PKC inhibitor.

Product Specification

Formula:C21H18ClNO4
 
MW:383.8
 
CAS:3895-92-9
 
MI:14: 2051
 
RTECS:FL9200000
 
Purity:≥98% (HPLC, TLC)
 
Appearance:Yellow solid.
 
Solubility:Soluble in DMSO, water (2mg/ml warm), 100% ethanol or methanol.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Heating to 40-50°C with gentle agitation may support complete solubilization. Further dilute with buffer just prior to use. Stock solutions should be refrigerated or frozen between for storage.
 
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Product Literature References

Chelerythrine and sanguinarine dock at distinct sites on BclXL that are not the classic BH3 binding cleft: Y.H. Zhang, et al.; J. Mol. Biol. 364, 536 (2006), Abstract;
The effect of chelerythrine on cell growth, apoptosis, and cell cycle in human normal and cancer cells in comparison with sanguinarine: J. Malikova, et al.; Cell Biol. Toxicol. 22, 439 (2006), Abstract;
Identification of chelerythrine as an inhibitor of BclXL function: S.L. Chan, et al.; J. Biol. Chem. 278, 20453 (2003), Abstract;
Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C: W.D. Jarvis, et al.; Cancer Res. 54, 1707 (1994), Abstract;
Antiplatelet effects of chelerythrine chloride isolated from Zanthoxylum simulans: F.N. Ko, et al.; Biochim. Biophys. Acta 1052, 360 (1990), Abstract;
Chelerythrine is a potent and specific inhibitor of protein kinase C: J.M. Herbert, et al.; BBRC 172, 993 (1990), Abstract;

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