Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

Chelerythrine chloride

PKC inhibitor
BML-EI225-0005 5 mg 94.00 USD
BML-EI225-0025 25 mg 390.00 USD
Do you need bulk/larger quantities?
Replaces Prod. #: ALX-350-008

Reported to be a potent and selective inhibitor of protein kinase C (IC50=0.66µM). Although chelerythrine has numerous documented biological effects, studies have raised serious doubts about the effectiveness of chelerythrine as a PKC inhibitor.

Product Specification

MI:14: 2051
Purity:≥98% (HPLC, TLC)
Appearance:Yellow solid.
Solubility:Soluble in DMSO, water (2mg/ml warm), 100% ethanol or methanol.
Long Term Storage:-20°C
Use/Stability:Heating to 40-50°C with gentle agitation may support complete solubilization. Further dilute with buffer just prior to use. Stock solutions should be refrigerated or frozen between for storage.
Please mouse over

Product Literature References

Follicle-Stimulating Hormone (FSH)-dependent Regulation of Extracellular Regulated Kinase (ERK) Phosphorylation by the Mitogen-activated Protein (MAP) Kinase Phosphatase MKP3: E.M. Donaubauer, et al.; J. Biol. Chem. 291, 19701 (2016), Application(s): Inhibition of MKP1 in Granulosa Cells, Abstract; Full Text
Chelerythrine and sanguinarine dock at distinct sites on BclXL that are not the classic BH3 binding cleft: Y.H. Zhang, et al.; J. Mol. Biol. 364, 536 (2006), Abstract;
The effect of chelerythrine on cell growth, apoptosis, and cell cycle in human normal and cancer cells in comparison with sanguinarine: J. Malikova, et al.; Cell Biol. Toxicol. 22, 439 (2006), Abstract;
Identification of chelerythrine as an inhibitor of BclXL function: S.L. Chan, et al.; J. Biol. Chem. 278, 20453 (2003), Abstract;
Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C: W.D. Jarvis, et al.; Cancer Res. 54, 1707 (1994), Abstract;
Antiplatelet effects of chelerythrine chloride isolated from Zanthoxylum simulans: F.N. Ko, et al.; Biochim. Biophys. Acta 1052, 360 (1990), Abstract;
Chelerythrine is a potent and specific inhibitor of protein kinase C: J.M. Herbert, et al.; BBRC 172, 993 (1990), Abstract;

Product Toolbox


Certificate of Analysis


By target:
By biological activity:
PKC Inhibitor
By catalog section:


Technical Service
Customer Service

Recommend this page

For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2019 Enzo Life Sciences, Inc.,