Chelerythrine chloride

PKC inhibitor



BML-EI225-0005	5 mg	77.00 USD

BML-EI225-0025	25 mg	309.00 USD

Replaces Prod. #: ALX-350-008

Reported to be a potent and selective inhibitor of protein kinase C (IC₅₀=0.66µM). Although chelerythrine has numerous documented biological effects, studies have raised serious doubts about the effectiveness of chelerythrine as a PKC inhibitor.

Product Specification

Formula:	C₂₁H₁₈ClNO₄

MW:	383.8

Purity:	98%

Appearance:	Yellow solid.

CAS:	3895-92-9

MI:	14: 2051

RTECS:	FL9200000

Solubility:	Soluble in DMSO, water (2mg/ml warm), 100% ethanol or methanol.

Long Term Storage:	-20°C

Use/Stability:	Heating to 40-50°C with gentle agitation may support complete solubilization. Further dilute with buffer just prior to use. Stock solutions should be refrigerated or frozen between for storage.

Hazard:	HARMFUL.

Background / Technical Information:	Please click here for the comprehensive product datasheet.

Please mouse over

Product Literature References

Chelerythrine and sanguinarine dock at distinct sites on BclXL that are not the classic BH3 binding cleft: Y.H. Zhang, et al.; J. Mol. Biol. 364, 536 (2006), Abstract;

The effect of chelerythrine on cell growth, apoptosis, and cell cycle in human normal and cancer cells in comparison with sanguinarine: J. Malikova, et al.; Cell Biol. Toxicol. 22, 439 (2006), Abstract;

Identification of chelerythrine as an inhibitor of BclXL function: S.L. Chan, et al.; J. Biol. Chem. 278, 20453 (2003), Abstract;

Induction of apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells by pharmacological inhibitors of protein kinase C: W.D. Jarvis, et al.; Cancer Res. 54, 1707 (1994), Abstract;

Antiplatelet effects of chelerythrine chloride isolated from Zanthoxylum simulans: F.N. Ko, et al.; Biochim. Biophys. Acta 1052, 360 (1990), Abstract;

Chelerythrine is a potent and specific inhibitor of protein kinase C: J.M. Herbert, et al.; BBRC 172, 993 (1990), Abstract;