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Tyrphostin 9

PDGF receptor inhibitor
 
BML-EI215-0050 50 mg 71.00 USD
 
BML-EI215-0250 250 mg 290.00 USD
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Replaces Prod. #: ALX-270-183

Tyrphostin 9 is a selective inhibitor of the PDGF receptor tyrosine kinase (IC50=1.2 µM). It is also a potent (10 nM) uncoupler of oxidative phosphorylation.

Product Specification

Alternative Name:RG-50872, Malonaben, SF 6847
 
Formula:C18H22N2O
 
MW:282.4
 
CAS:10537-47-0
 
RTECS:OO3737000
 
Purity:≥99% (HPLC)
 
Appearance:Yellow solid.
 
Solubility:Soluble in DMSO (>25mg/ml) or ethanol (20mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Handling:Store tightly sealed in the dark. Protect from light.
 
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Product Literature References

Chemosensitization of glioblastoma cells to bis-dichloroethyl-nitrosourea with tyrphostin AG17: B.C. Liang & E. Ullyatt; Clin. Cancer Res. 4, 773 (1998), Abstract;
The tryphostin AG17 induces apoptosis and inhibition of cdk2 activity in a lymphoma cell line that overexpresses bcl-2: G.A. Palumbo, et al.; Cancer Res. 57, 2434 (1997), Abstract;
Tyrphostin AG17, [(3,5-Di-tert-butyl-4-hydroxybenzylidene)- malononitrile], inhibits cell growth by disrupting mitochondria: A.M. Burger, et al.; Cancer Res. 55, 2794 (1995), Abstract;
Tyrphostins as molecular tools and potential antiproliferative drugs: A. Levitzki & C. Gilon; Trends Pharmacol. Sci. 12, 171 (1991), Abstract;
Tyrphostins inhibit PDGF-induced DNA synthesis and associated early events in smooth muscle cells: G.E. Bilder, et al.; Am. J. Physiol. 260, C721 (1991), Abstract;
The interaction of highly active uncouplers with mitochondria: H. Terada; Biochim. Biophys. Acta 639, 225 (1981), Abstract;

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