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L-655,238

Lipoxygenase inhibitor
 
BML-EI210-0010 10 mg 84.00 USD
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Replaces Prod. #: ALX-270-077

Potent and selective inhibitor (IC50=100nM) of 5-LO-activating protein (FLAP).

Product Specification

Alternative Name:α-Pentyl-3-(2-quinolinylmethoxy)-benzenemethanol, REV-5901 para isomer
 
Formula:C22H25NO2
 
MW:335.4
 
CAS:101910-24-1
 
Purity:≥99% (TLC)
 
Appearance:Off-white to tan solid.
 
MeltingPoint:92-93°C
 
Solubility:Soluble in ethanol (10mg/ml) and DMSO (10mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C.
 
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Product Literature References

5-Lipoxygenase-activating protein is the target of a quinoline class of leukotriene synthesis inhibitors.: J.F. Evans, et al.; Mol. Pharmacol. 40, 22 (1991), Abstract;
FLAP: a novel drug target for inhibiting the synthesis of leukotrienes.: A.W. Ford-Hutchinson; Trends Pharmacol. Sci. 12, 68 (1991), Abstract;

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