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REV-5901

Lipoxygenase inhibitor
 
BML-EI209-0050 50 mg 263.00 USD
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A dual activity leukotriene D4 antagonist (Ki=0.7 µM, inhibition of [3H]-LTD4 binding to guinea pig lung membranes) and 5-lipoxygenase inhibitor (IC50=6 µM).

Product Specification

Formula:C22H25NO2
 
MW:335.4
 
CAS:101910-24-1
 
Purity:≥98% (TLC)
 
Appearance:White to off-white solid.
 
MeltingPoint:66-69°C
 
Solubility:Soluble in ethanol (10 mg/ml) or DMSO (10 mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months.
 
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Product Literature References

Persistent intracellular binding of mitoxantrone in a human colon carcinoma cell line: E.J. Kusner, et al.; Biochem. Pharmacol. 38, 4283 (1989), Abstract;
REV 5901: an orally effective peptidoleukotriene antagonist, detailed biochemical/pharmacological profile: R.G. VanInwegen, et al.; J. Pharmacol. Exp. Ther. 241, 117 (1987), Abstract;

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