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Auranofin

Anti-arthritic agent
 
BML-EI206-0100 100 mg 82.00 USD
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Replaces Prod. #: ALX-430-064

Gold derivative. Widely used as an anti-arthritic drug. Inhibits various leukocyte activation pathways at multiple sites. Inhibits release of inflammatory mediators from human basophils, pulmonary mast cells and macrophages. Also inhibits human neutrophil 5-lipoxygenase. Inhibits IκB kinase (IKK) by modifying Cys179 of the IKKß subunit. Efficient inducer of mitochondrial membrane permeability transition pore in the presence of calcium ions, potentially referable to its inhibition of mitochondrial thioredoxin reductase.

Product Specification

Alternative Name:SKF 39162, 1-Thio-β-D-glucopyranosatotriethyl phosphine gold-2,3,4,6-tetraacetate
 
Formula:C20H34AuO9PS
 
MW:678.5
 
CAS:34031-32-8
 
MI:14: 878
 
Purity:≥98% (HPLC)
 
Appearance:White solid.
 
Solubility:Soluble in DMSO (5mg/ml) or 100% ethanol (4mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C.
 
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Product Literature References

Thioredoxin-Mimetic-Peptides Protect Cognitive Function after Mild Traumatic Brain Injury (mTBI): R. Baratz-Goldstein, et al.; PLoS One 11, e0157064 (2016), Application(s): MAPK Activity (human neuronal cells), Abstract; Full Text
Auranofin-induced oxidative stress causes redistribution of the glutathione pool in Taenia crassiceps cysticerci: J.J. Martínez-González, et al.; Mol. Biochem. Parasitol. 201, 16 (2015), Application(s): Cell Culture, Abstract;
Disruption of thioredoxin metabolism enhances the toxicity of transforming growth factor β-activated kinase 1 (TAK1) inhibition in KRAS-mutated colon cancer cells: J. E. Hrabe, et al.; Redox Biol. 5, 319 (2015), Application(s): Cell Culture, Abstract;
Repurposing auranofin as a lead candidate for treatment of lymphatic filariasis and onchocerciasis: C. A. Bulman, et al.; PLoS Negl. Trop. Dis. 9, e0003534 (2015), Application(s): Incubation, Abstract; Full Text
Suppressive Role of PPARγ-Regulated Endothelial Nitric Oxide Synthase in Adipocyte Lipolysis: Y. Yamada, et al.; PLoS One 10, e0136597 (2015), Application(s): Suppressed lipolysis, Abstract; Full Text
Gold drug auranofin could reduce neuroinflammation by inhibiting microglia cytotoxic secretions and primed respiratory burst: J.M. Maderira, et al.; J. Neuroimmunol. 276, 71 (2014), Application(s): Cell culture, Abstract;
Novel protective properties of auranofin: inhibition of human astrocyte cytotoxic secretions and direct neuroprotection: J.M. Maderira, et al.; Life Sci. 92, 1072 (2013), Application(s): Cell culture, Abstract;
Respiration-dependent H2O2 removal in brain mitochondria via the thioredoxin/peroxiredoxin system: D.A. Drechsel & M. Patel; J. Biol. Chem. 285, 27850 (2010), Abstract; Full Text
Induction of mitochondrial permeability transition by auranofin, a gold(I)-phosphine derivative: M.P. Rigobello, et al.; Br. J. Pharmacol. 136, 1162 (2002), Abstract;
Auranofin inhibits the activation pathways of polymorphonuclear leukocytes at multiple sites: R. Rudkowski, et al.; Biochem. Pharmacol. 41, 1921 (1991), Abstract;
Auranofin stimulates LTA hydrolase and inhibits 5-lipoxygenase/LTA synthase activity of isolated human neutrophils: W.H. Betts, et al.; Biochem. Pharmacol. 39, 1233 (1990), Abstract;
Modulation of mediator release from human basophils and pulmonary mast cells and macrophages by auranofin: M. Columbo, et al.; Biochem. Pharmacol. 39, 285 (1990), Abstract;
Antiarthritic gold compounds effectively quench electronically excited singlet oxygen: E.J. Corey, et al.; Science 236, 68 (1987), Abstract;

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