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Tyrphostin 23 (RG-50810)

EGFR inhibitor
 
BML-EI191-0010 10 mg 77.00 USD
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Replaces Prod. #: ALX-270-129

A potent inhibitor of EGF receptor kinase activity (IC50=35 µM).

Product Specification

Alternative Name:α-Cyano-(3,4-dihydroxy)cinnamonitrile
 
Formula:C10H6N2O2
 
MW:186.1
 
CAS:118409-57-7
 
Purity:≥99% (TLC)
 
Appearance:Yellow-tan solid.
 
Solubility:Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Product is subject to oxidation.
 
Handling:Store tightly sealed in the dark. Protect from light. Make solutions fresh daily.
 
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Product Literature References

Differential activation of mitogen-activated protein kinase and S6 kinase signaling pathways by 12-O-tetradecanoylphorbol-13-acetate (TPA) and insulin. Evidence for involvement of a TPA-stimulated protein-tyrosine kinase: R. Seger, et al.; J. Biol. Chem. 270, 28325 (1995), Abstract;
Role of tyrosine kinase and protein kinase C in the steroidogenic actions of angiotensin II, alpha-melanocyte-stimulating hormone and corticotropin in the rat adrenal cortex: S. Kapas, et al.; Biochem. J. 305 (Pt2), 433 (1995), Abstract;
Cholecystokinin rapidly activates mitogen-activated protein kinase in rat pancreatic acini: R.D. Duan & J.A. Williams; Am. J. Physiol. 267, G401 (1994), Abstract;
Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors: A. Gazit, et al.; J. Med. Chem. 32, 2344 (1989), Abstract;
Tyrphostins inhibit epidermal growth factor (EGF)-receptor tyrosine kinase activity in living cells and EGF-stimulated cell proliferation: R.M. Lyall, et al.; J. Biol. Chem. 264, 14503 (1989), Abstract;
Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors: P. Yaish, et al.; Science 242, 933 (1988), Abstract;

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