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Tyrphostin 47 (RG-50864) (AG-213)

EGFR inhibitor
 
BML-EI188-0005 5 mg 83.00 USD
 
BML-EI188-0025 25 mg 308.00 USD
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Replaces Prod. #: ALX-270-132

A potent inhibitor of EGF receptor kinase activity (IC50‘s:EGFR = 2.4 µM, PDGFR = 3.5 µM, p210bcr-abl=5.9 µM, insulin receptor = 640 µM).

Product Specification

Formula:C10H8N2O2S
 
MW:220.2
 
CAS:122520-86-9
 
Purity:≥99% (TLC)
 
Appearance:Orange solid.
 
Solubility:Soluble at 20 mg/ml in 100% ethanol or DMSO.
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Store, as supplied, at room temperature for up to 1 year. Product is subject to oxidation. Make solutions fresh daily.
 
Handling:Store tightly sealed in the dark. Protect from light.
 
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Product Literature References

Tyrosine kinase inhibition: an approach to drug development: A. Levitsk & A. Gazit; Science 267, 1782 (1995), Abstract;
Tyrphostins as molecular tools and potential antiproliferative drugs: A. Levitzki & C. Gilon; Trends Pharmacol. Sci. 12, 171 (1991), Abstract;
Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors: A. Gazit, et al.; J. Med. Chem. 32, 2344 (1989), Abstract;
Tyrphostins inhibit epidermal growth factor (EGF)-receptor tyrosine kinase activity in living cells and EGF-stimulated cell proliferation: R.M. Lyall, et al.; J. Biol. Chem. 264, 14503 (1989), Abstract;
Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors: P. Yaish, et al.; Science 242, 933 (1988), Abstract;

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