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Tyrphostin 25 (RG-50875)

EGFR inhibitor
 
BML-EI187-0005 5 mg 72.00 USD
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Replaces Prod. #: ALX-270-130

A potent inhibitor of EGF receptor kinase activity (IC50=3 µM).

Product Specification

Formula:C10H6N2O3
 
MW:202.2
 
CAS:118409-58-8
 
Purity:≥99%
 
Appearance:Yellow-orange solid.
 
Solubility:Soluble in 100% ethanol or DMSO.
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Store, as supplied, at room temperature for up to 1 year. Product is subject to oxidation. Make solutions fresh daily.
 
Handling:Store tightly sealed in the dark. Protect from light.
 
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Product Literature References

Inhibition of epidermal-growth-factor-receptor-dependent signalling by tyrphostins A25 and AG1478 blocks growth and induces apoptosis in colorectal tumor cells in vitro: G. Partik, et al.; J. Cancer Res. Clin. Oncol. 125, 379 (1999), Abstract;
Inhibition of GTP-utilizing enzymes by tyrphostins: G. Wolbring, et al.; J. Biol. Chem. 269, 22470 (1994), Abstract;
Inhibitors of tyrosine phosphorylation induce apoptosis in human leukemic cell lines: G. Bergamaschi, et al.; Leukemia 7, 2012 (1993), Abstract;
Tyrphostins inhibit PDGF-induced DNA synthesis and associated early events in smooth muscle cells: G.E. Bilder, et al.; Am. J. Physiol. 260, C721 (1991), Abstract;
Tyrphostins I: synthesis and biological activity of protein tyrosine kinase inhibitors: A. Gazit, et al.; J. Med. Chem. 32, 2344 (1989), Abstract;
Blocking of EGF-dependent cell proliferation by EGF receptor kinase inhibitors: P. Yaish, et al.; Science 242, 933 (1988), Abstract;

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