ACA is a close structural analog of the PLA2 inhibitor, ONO-RS-082 and possesses similar but less potent inhibitory activity. Inhibits TRP channels independently of PLA2, including TRPM2, TRPC6 and TRPM8. It is a useful tool for studying the physiological role of TRP channels.
Product Details
| Alternative Name: | ACA |
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| Formula: | C21H23NO3 |
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| MW: | 337.4 |
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| CAS: | 110683-10-8 |
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| Purity: | ≥99% (HPLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in DMSO (50 mg/ml) or ethanol (50 mg/ml @ 60°C). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Store, as supplied, at room temperature for up to 1 year. Make solutions fresh daily. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Development and validation of a cell-based high-throughput screening assay for TRPM2 channel modulators: Y. Song, et al.; J. Biomol. Screen.
13, 54 (2008),
Abstract;
N-(p-amylcinnamoyl)anthranilic acid (ACA): a phospholipase A(2) inhibitor and TRP channel blocker: C. Hartenec, et al.; Cardiovasc. Drug Rev.
25, 61 (2007),
Abstract;
Inhibition of TRPM2 cation channels by N-(p-amylcinnamoyl)anthranilic acid: R. Kraft, et al.; Br. J. Pharmacol.
148, 264 (2006),
Abstract;
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Inhibition of glucose-induced insulin secretion by the diacylglycerol lipase inhibitor RHC 80267 and the phospholipase A2 inhibitor ACA through stimulation of K+ permeability without diminution by exogenous arachidonic acid: P. Thams & K. Capito; Biochem. Pharmacol.
53, 1077 (1997),
Abstract;
Activation of phospholipases A and C in human platelets exposed to epinephrine: role of glycoproteins IIb/IIIa and dual role of epinephrine: H. S. Banga, et al.; Proc. Natl. Acad. Sci. USA
83, 9197 (1986),
Abstract;
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