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Bumetanide

Na+ channel blocker
 
BML-EI168-0005 5 g 199.00 USD
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Replaces Prod. #: ALX-550-238

Bumetanide is a specific inhibitor of Na-K-2Cl cotransport. It binds specifically, saturably and with high affinity to membranes from a large variety of cells. A clinically useful diuretic.

Product Specification

Formula:C17H20N2O5S
 
MW:364.4
 
CAS:28395-03-1
 
Purity:≥98%
 
Appearance:White solid.
 
Solubility:Soluble in DMSO (25mg/ml) or 100% ethanol (10mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
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Product Literature References

Pharmacokinetics and pharmacodynamics of the diuretic bumetanide in the elderly: R. Oberbauer, et al.; Clin. Pharmacol. Ther. 57, 42 (1995), Abstract;
Effect of bradykinin on Na-K-2Cl cotransport and bumetanide binding in aortic endothelial cells: J.D. Klein & W.C. O'Neill; J. Biol. Chem. 265, 22238 (1990), Abstract;
The regulation of Na/K/2Cl cotransport and bumetanide binding in avian erythrocytes by protein phosphorylation and dephosphorylation. Effects of kinase inhibitors and okadaic acid: E.B. Pewitt, et al.; J. Biol. Chem. 265, 20747 (1990), Abstract;
Characteristics and functions of Na-K-Cl cotransport in epithelial tissues: S.M. O'Grady, et al.; Am. J. Physiol. 253, C177 (1987), Abstract;

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