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Ibuprofen

COX inhibitor
 
BML-EI164-0005 5 g 86.00 USD
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Replaces Prod. #: ALX-550-249

Selective cyclooxygenase (COX) inhibitor (IC50=14.9 µM). Inhibits PGH synthase-1 and PGH synthase-2 with comparable potency (ID50=8.9-14 and 7.2-8.2 µM respectively; data are for (S) isomer). Clinically useful NSAID. Inhibits the neutrophil-dependent edema response of rabbit skin to C5a/PGE2.

Product Specification

Alternative Name:α-Methyl-4-(2-methylpropyl)benzeneacetic acid, (±)-2-(4-Isobutylphenyl)propionic acid
 
Formula:C13H18O2
 
MW:206.3
 
CAS:15687-27-1
 
MI:14: 4881
 
Purity:≥99% (HPLC)
 
Appearance:White solid.
 
Solubility:Soluble in ethanol (25mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C.
 
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Product Literature References

Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs: E.A. Meade, et al.; J. Biol. Chem. 268, 6610 (1993), Abstract;
Suppression of inflammatory oedema by ibuprofen involving a mechanism independent of cyclo-oxygenase inhibition: M. Rampart & T.J. Williams; Biochem. Pharmacol. 35, 581 (1986), Abstract;
Differential effects of anti-inflammatory drugs on lipoxygenase and cyclo-oxygenase activities of neutrophils from a reverse passive Arthus reaction: R.F. Myers & M.I. Siegel; Biochem. Biophys. Res. Commun. 112, 586 (1983), Abstract;

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