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H-8 . 2HCl

PKA inhibitor
 
BML-EI158-0010 10 mg 88.00 USD
 
BML-EI158-0050 50 mg 362.00 USD
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Replaces Prod. #: ALX-270-067

H-8 inhibits PKA and PKG selectively over PKC and MLCK (IC50’s=1.2μM, 0.48μM, 15μM and 68μM respectively). It also inhibits myosin light chain kinase.

Product Specification

Formula:C12H15N3O2S . 2HCl
 
MW:338.3
 
CAS:84478-11-5
 
Purity:≥98% (TLC)
 
Appearance:White to off-white solid.
 
Solubility:Soluble in DMSO (25mg/ml) and ethanol/water (1:1, 25mg/ml).
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
Use/Stability:Store, as supplied, at 0-4°C for up to 1 year. Store solutions at -20°C for up to 3 months.
 
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Product Literature References

Crystal structures of catalytic subunit of cAMP-dependent protein kinase in complex with isoquinolinesulfonyl protein kinase inhibitors H7, H8, and H89. Structural implications for selectivity.: R.A. Engh, et al.; J. Biol. Chem. 271, 26157 (1996), Abstract;
Differential growth inhibition of isoquinolinesulfonamides H-8 and H-7 towards multidrug-resistant P388 murine leukaemia cells.: M. Ido, et al.; Br. J. Cancer 64, 1103 (1991), Abstract;
Selective modulation of calcium-dependent myosin phosphorylation by novel protein kinase inhibitors, isoquinolinesulfonamide derivatives.: M. Hagiwara, et al.; Mol. Pharmacol. 32, 7 (1987), Abstract;
Specific binding of a novel compound, N-[2-(methylamino)ethyl]-5-isoquinolinesulfonamide (H-8) to the active site of cAMP-dependent protein kinase.: M. Hagiwara, et al.; Mol. Pharmacol. 31, 523 (1987), Abstract;
Naphthalenesulfonamides as calmodulin antagonists and protein kinase inhibitors.: M. Inagaki, et al.; Mol. Pharmacol. 29, 577 (1986), Abstract;
Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C.: H. Hidaka, et al.; Biochemistry 23, 5036 (1984), Abstract;

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