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1-O-Hexadecyl-2-O-acetyl-sn-glycerol

PKC inhibitor
 
BML-EI150-0005 5 mg 105.00 USD
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Replaces Prod. #: ALX-300-078

Inhibits protein kinase C activation by diacylglycerols. Stimulates HL-60 cell differentiation. Biosynthetic precursor of PAF via remodeling and retroconversion/de novo routes. Induces delayed aggregation of rabbit platelets. Mitogenic for smooth muscle cells.

Product Specification

Formula:C21H42O4
 
MW:358.6
 
CAS:77133-35-8
 
Purity:≥95% (TLC)
 
Appearance:Waxy solid.
 
Solubility:Soluble in 100% ethanol or acetone.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 6 months at -20°C.
 
Handling:Hygroscopic. Protect from moisture.
 
Technical Info/Product Notes:Avoid acidic or basic conditions. Note: Product is not sterile
 
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Product Literature References

Platelet Activating Factor (PAF) biosynthesis is inhibited by phenolic compounds in U-937 cells under inflammatory conditions: I.C. Vlachogianni, et al.; Prostaglandins Other Lipid Mediat. 121, 176 (2015), Abstract;
Regulation of the synthesis of platelet-activating factor and its inactive storage precursor (1-alkyl-2-acyl-sn-glycero-3-phosphocholine) from 1-alkyl-2-acetyl-sn-glycerol by rabbit platelets: T.C. Lee, et al.; J. Biol. Chem. 265, 9181 (1990), Abstract;
1-O-alkyl-2-acetyl-sn-glycerol: a platelet-activating factor metabolite with biological activity in vascular smooth muscle cells: L.L. Stoll, et al.; Cell Regul. 1, 13 (1989), Abstract;
Alkyl-linked diglycerides inhibit protein kinase C activation by diacylglycerols: L.W. Daniel, et al.; BBRC 151, 291 (1988), Abstract;
1-0-Hexadecyl-2-acetyl-sn-glycerol stimulates differentiation of HL-60 human promyelocytic leukemia cells to macrophage-like cells: M.J.C. McNamara, et al.; BBRC 122, 824 (1984), Abstract;
A new class of antihypertensive neutral lipid: 1-alkyl-2-acetyl-sn- glycerols, a precursor of platelet activating factor: M.L. Blank, et al.; BBRC 118, 344 (1984), Abstract;
Conversion of 1-alkyl-2-acetyl-sn-glycerols to platelet activating factor and related phospholipids by rabbit platelets: M.L. Blank, et al.; BBRC 124, 156 (1984), Abstract;
Metabolism of 1-O-alkyl-2-acetyl-sn-glycerol by washed rabbit platelets: formation of platelet activating factor: K. Satouchi, et al.; Arch. Biochem. Biophys. 234, 318 (1984), Abstract;

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