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Erbstatin Analog

EGFR inhibitor
 
BML-EI146-0005 5 mg 89.00 USD
 
BML-EI146-0025 25 mg 299.00 USD
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Replaces Prod. #: ALX-270-098

Erbstatin is a novel inhibitor of the EGF receptor-associated tyrosine kinase. It is an unstable compound and is completely inactivated in serum in 30 minutes. Methyl 2,5-dihydroxycinnamate is a stable erbstatin analog retaining activity after a 60 minute incubation. It inhibits EGF receptor-associated tyrosine kinase in vitro (IC50=0.77 µM). Inhibition is competitive with substrate and noncompetitive with ATP.

Product Specification

Alternative Name:Methyl 2,5-dihydroxycinnamate
 
Formula:C10H10O4
 
MW:194.2
 
CAS:63177-57-1
 
Purity:≥98% (TLC)
 
Appearance:Yellow solid.
 
MeltingPoint:169-172°C
 
Solubility:Soluble in ethanol (25mg/ml), methanol or DMSO (25mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C.
 
Handling:Protect from light and oxygen.
 
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Product Literature References

Induction of mouse thymocyte apoptosis by inhibitors of tyrosine kinases is associated with dephosphorylation of nuclear proteins: Y. Azuma, et al.; Cell. Immunol. 152, 271 (1993), Abstract;
Inhibition of Abelson oncogene function by erbstatin analogues: M. Kawada, et al.; Drugs Exp. Clin. Res. 19, 235 (1993), Abstract;
Inhibition of epidermal growth factor receptor functions by tyrosine kinase inhibitors in NIH3T3 cells: K. Umezawa, et al.; FEBS Lett. 314, 289 (1992), Abstract;
Inhibition of epidermal growth factor-induced DNA synthesis by tyrosine kinase inhibitors: K. Umezawa, et al.; FEBS Lett. 260, 198 (1990), Abstract;
In situ inhibition of tyrosine protein kinase by erbstatin: M. Imoto, et al.; Biochem. Int. 15, 989 (1987), Abstract;

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