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Acivicin

 
BML-EI113-0010 10 mg 220.00 USD
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Irreversible inhibitor of γ-glutamyl transpeptidase (GGT) ID50 = 0.54 mM. Inhibits the enzymatic conversion of leukotriene C4 to leukotriene D4. Displays antitumor and anti-metastatic activity. Blocks H. Pylori GGT-induced T-cell inhibition. Inhibits bioactivation/release of nitric oxide from GSNO.

Product Specification

Alternative Name:U-42126, AT-125
 
Formula:C5H7ClN2O3
 
MW:178.6
 
CAS:42228-92-2
 
Purity:≥99% (HPLC)
 
Appearance:White solid.
 
Solubility:Soluble in water (max. 18mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
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Product Literature References

A Cytotoxic, Co-operative Interaction Between Energy Deprivation and Glutamate Release From System xc- Mediates Aglycemic Neuronal Cell Death: T.L. Thorn, et al.; ASN Neuro. 7, 1177 (2015), Application(s): Cell culture , Abstract; Full Text
A novel, species-specific class of uncompetitive inhibitors of gamma-glutamyl transpeptidase: J.B. King, et al.; J. Biol. Chem. 284, 9059 (2009), Abstract;
Inhibition of T-cell proliferation by Helicobacter pylori gamma-glutamyl transpeptidase: C. Schmees, et al.; Gastroenterology 132, 1820 (2007), Abstract;
Inhibition of gamma-glutamyl transpeptidase activity decreases intracellular cysteine levels in cervical carcinoma: P. Ruoso & D.W. Hedley; Cancer Chemother. Pharmacol. 54, 49 (2004), Abstract;
gamma-Glutamyl transpeptidase overexpression increases metastatic growth of B16 melanoma cells in the mouse liver: E. Obrador, et al.; Hepatology 35, 74 (2002), Abstract;
S-Nitrosoglutathione as a substrate for gamma-glutamyl transpeptidase: N. Hogg, et al.; Biochem. J. 323 (Pt2), 477 (1997), Abstract;
Metabolism and action of amino acid analog anti-cancer agents: G.S. Ahluwalia et al.; Pharmacol. Ther. 46, 243 (1990), Abstract;
Excretion of cysteine and gamma-glutamylcysteine moieties in human and experimental animal gamma-glutamyl transpeptidase deficiency: O.W. Griffith & A. Meister; PNAS 77, 3384 (1980), Abstract;
The inhibition of gamma-glutamyl transpeptidase from human pancreatic carcinoma cells by (alpha S,5S)-alpha-amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid (AT-125; NSC-163501): L. Allen, et al.; Res. Commun. Chem. Pathol. Pharmacol. 27, 175 (1980), Abstract;

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