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7,7-Dimethyleicosadienoic acid

Phospholipase inhibitor
 
BML-EI112-0010 10 mg 85.00 USD
 
BML-EI112-0050 50 mg 332.00 USD
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Replaces Prod. #: ALX-340-008

Non-metabolizable analog of arachidonic or eicosadienoic acid. Cell permeable. DEDA inhibits P388D1 cell phospholipase A2 (PLA2) (IC50=16 µM) and snake venom PLA2 (IC50=14 µM). It inhibits human recombinant sPLA2 (IC50=5.8 µM) selectively over cPLA2. It is also a weak inhibitor of 5-lipoxygenase (IC50=56 µM, RBL-l cells). Inhibits induction of the anti-viral state in human fibroblasts induced by interferon.

Product Specification

Alternative Name:DEDA
 
Formula:C22H40O2
 
MW:336.6
 
CAS:89560-01-0
 
Purity:≥99%
 
Appearance:Viscous colorless or pale yellow oil.
 
Solubility:Soluble in 100% ethanol or methanol.
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
Use/Stability:Store, as supplied, at 4°C for up to 1 year. Store solutions at -20°C for up to 6 months.
 
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Product Literature References

Secretory phospholipase A2 inhibitors and calmodulin antagonists as inhibitors of cytosolic phospholipase A2: W.C. Hope, et al.; Agents Actions 39, C39 (1993), Abstract;
Effect of the phospholipase A2 inhibitors quinacrine and 7,7-dimethyleicosadienoic acid in isolated globally ischemic rat hearts: C.A. Sargent, et al.; J. Pharmacol. Exp. Ther. 262, 1161 (1992), Abstract;
Arachidonic acid regulates the binding of human interferon in human skin fibroblasts: S.D. Menon, et al.; Lipids 25, 321 (1990), Abstract;
Inhibition studies on the membrane-associated phospholipase A2 in vitro and prostaglandin E2 production in vivo of the macrophage-like P388D1 cell. Effects of manoalide, 7,7-dimethyl-5,8-eicosadienoic acid, and p-bromophenacyl bromide: M.D. Lister, et al.; J. Biol. Chem. 264, 8520 (1989), Abstract;
Analogs of arachidonic acid methylated at C-7 and C-10 as inhibitors of leukotriene biosynthesis: N. Cohen, et al.; Prostaglandins 27, 553 (1984), Abstract;

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