Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

Baicalein

Lipoxygenase inhibitor
 
BML-EI106-0010 10 mg 68.00 USD
 
BML-EI106-0050 50 mg 263.00 USD
Do you need bulk/larger quantities?
 
Replaces Prod. #: ALX-385-022

Inhibits cellular Ca2+ uptake and calcium mobilization. Inhibitor of protein tyrosine kinase in leukemia (CEM) cells. Induces cell cycle arrest and apoptosis. Anti-inflammatory compound. Has anti-thrombotic, anti-proliferative and anti-mitogenic effects.Originally reported as a selective inhibitor of 12-lipoxygenase, baicalein has since been shown to inhibit both 12-LO and 15-LO (IC50=0.64µM for 12-LO and 1.6µM for 15-LO). Inhibits leukotriene biosynthesis (at higher concentrations) and release of lysosomal enzymes. Inhibits adjuvant-induced arthritis. Also inhibits prolyl oligopeptidase (POP/PREP)(IC50=36µM).

Product Specification

Alternative Name:5,6,7-Trihydroxyflavone
 
Formula:C15H10O5
 
MW:270.2
 
CAS:491-67-8
 
MI:14: 942
 
Purity:≥98% (HPLC)
 
Appearance:Yellow to yellow-green crystalline powder.
 
Solubility:Soluble in DMSO, acetone, 100% ethanol or methanol; almost insoluble in water.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Subject to oxidation.
 
Handling:Protect from light.
 
ALX-385-022
Please mouse over
ALX-385-022

Product Literature References

Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor: T. Tarrago, et al.; Bioorg. Med. Chem. 16, 7516 (2008), Abstract;
Neuroprotective effect of baicalein against MPTP neurotoxicity: behavioral, biochemical and immunohistochemical profile: Y. Chang, et al.; Neurosci. Lett. 441, 16 (2008), Abstract;
Baicalein inhibition of hydrogen peroxide-induced apoptosis via ROS-dependent heme oxygenase 1 gene expression: H.Y. Lin, et al.; Biochim. Biophys. Acta 1773, 1073 (2007), Abstract;
Baicalein is a potent in vitro inhibitor against both reticulocyte 15-human and platelet 12-human lipoxygenases: J. D. Deschamps, et al.; Bioorg. Med. Chem. 14, 4295 (2006), Abstract;
Baicalein induced cell cycle arrest and apoptosis in human lung squamous carcinoma CH27 cells: H.Z. Lee, et al.; Anticancer Res. 25, 959 (2005), Abstract;
Biological properties of baicalein in cardiovascular system: Y. Huang, et al.; Curr. Drug Targets Cardiovasc. Haematol. Disord. 5, 177 (2005), (Review), Abstract;
Mechanisms in mediating the anti-inflammatory effects of baicalin and baicalein in human leukocytes: Y.C. Shen, et al.; Eur. J. Pharmacol. 465, 171 (2003), Abstract;
Baicalein induces a dual growth arrest by modulating multiple cell cycle regulatory molecules: S.L. Hsu, et al.; Eur. J. Pharmacol. 425, 165 (2001), Abstract;
Protective effects of baicalein against cell damage by reactive oxygen species: D. Gao, et al.; Chem. Pharm. Bull. (Tokyo) 46, 1383 (1998), Abstract;
Arachidonic acid metabolites in bFGF-, PDGF-, and serum-stimulated vascular cell growth: S.M. Dethlefsen, et al.; Exp. Cell Res. 212, 262 (1994), Abstract;
Effects of baicalein and esculetin on transduction signals and growth factors expression in T-lymphoid leukemia cells: H.C. Huang, et al.; Eur. J. Pharmacol. 268, 73 (1994), Abstract;
Anti-inflammatory properties and inhibition of leukotriene C4 biosynthesis in vitro by flavonoid baicalein from Scutellaria baicalensis georgy roots: I.G. Butenko, et al.; Agents Actions 39 Spec No, C49 (1993), Abstract;
Biliary excretion of metabolites of baicalin and baicalein in rats: K. Abe, et al.; Chem. Pharm. Bull. 38, 209 (1990), Abstract;
Inhibition of reverse transcriptase activity by a flavonoid compound, 5,6,7-trihydroxyflavone: K. Ono, et al.; BBRC 160, 982 (1989), Abstract;
Specific action of the lipoxygenase pathway in mediating angiotensin II- induced aldosterone synthesis in isolated adrenal glomerulosa cells: J.L. Nadler, et al.; J. Clin. Invest. 80, 1763 (1987), Abstract;
Selective inhibition of platelet lipoxygenase by baicalein: K. Sekiya & H. Okuda; BBRC 105, 1090 (1982), Abstract;

Related Literature

Brochures
Comprehensive Tools for Quantifying Cellular Responses to Oxidative Damage
Comprehensive Tools for Quantifying Cellular Responses to Oxidative Damage
Download as PDF

Technical Posters
Arachidonic Acid Metabolites
Arachidonic Acid Metabolites
Download as PDF

Technical Posters
Disease-Associated Stress Signaling
Disease-Associated Stress Signaling
Download as PDF

All new literature pieces

Recommend this page

 
Keep in touch

©2017 Enzo Life Sciences, Inc.,