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Lipoxygenase inhibitor
BML-EI106-0010 10 mg 68.00 USD
BML-EI106-0050 50 mg 263.00 USD
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Replaces Prod. #: ALX-385-022

Inhibits cellular Ca2+ uptake and calcium mobilization. Inhibitor of protein tyrosine kinase in leukemia (CEM) cells. Induces cell cycle arrest and apoptosis. Anti-inflammatory compound. Has anti-thrombotic, anti-proliferative and anti-mitogenic effects.Originally reported as a selective inhibitor of 12-lipoxygenase, baicalein has since been shown to inhibit both 12-LO and 15-LO (IC50=0.64µM for 12-LO and 1.6µM for 15-LO). Inhibits leukotriene biosynthesis (at higher concentrations) and release of lysosomal enzymes. Inhibits adjuvant-induced arthritis. Also inhibits prolyl oligopeptidase (POP/PREP)(IC50=36µM).

Product Specification

Alternative Name:5,6,7-Trihydroxyflavone
MI:14: 942
Purity:≥98% (HPLC)
Appearance:Yellow to yellow-green crystalline powder.
Solubility:Soluble in DMSO, acetone, 100% ethanol or methanol; almost insoluble in water.
Long Term Storage:-20°C
Use/Stability:Subject to oxidation.
Handling:Protect from light.
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Product Literature References

Baicalin, a prodrug able to reach the CNS, is a prolyl oligopeptidase inhibitor: T. Tarrago, et al.; Bioorg. Med. Chem. 16, 7516 (2008), Abstract;
Neuroprotective effect of baicalein against MPTP neurotoxicity: behavioral, biochemical and immunohistochemical profile: Y. Chang, et al.; Neurosci. Lett. 441, 16 (2008), Abstract;
Baicalein inhibition of hydrogen peroxide-induced apoptosis via ROS-dependent heme oxygenase 1 gene expression: H.Y. Lin, et al.; Biochim. Biophys. Acta 1773, 1073 (2007), Abstract;
Baicalein is a potent in vitro inhibitor against both reticulocyte 15-human and platelet 12-human lipoxygenases: J. D. Deschamps, et al.; Bioorg. Med. Chem. 14, 4295 (2006), Abstract;
Baicalein induced cell cycle arrest and apoptosis in human lung squamous carcinoma CH27 cells: H.Z. Lee, et al.; Anticancer Res. 25, 959 (2005), Abstract;
Biological properties of baicalein in cardiovascular system: Y. Huang, et al.; Curr. Drug Targets Cardiovasc. Haematol. Disord. 5, 177 (2005), (Review), Abstract;
Mechanisms in mediating the anti-inflammatory effects of baicalin and baicalein in human leukocytes: Y.C. Shen, et al.; Eur. J. Pharmacol. 465, 171 (2003), Abstract;
Baicalein induces a dual growth arrest by modulating multiple cell cycle regulatory molecules: S.L. Hsu, et al.; Eur. J. Pharmacol. 425, 165 (2001), Abstract;
Protective effects of baicalein against cell damage by reactive oxygen species: D. Gao, et al.; Chem. Pharm. Bull. (Tokyo) 46, 1383 (1998), Abstract;
Arachidonic acid metabolites in bFGF-, PDGF-, and serum-stimulated vascular cell growth: S.M. Dethlefsen, et al.; Exp. Cell Res. 212, 262 (1994), Abstract;
Effects of baicalein and esculetin on transduction signals and growth factors expression in T-lymphoid leukemia cells: H.C. Huang, et al.; Eur. J. Pharmacol. 268, 73 (1994), Abstract;
Anti-inflammatory properties and inhibition of leukotriene C4 biosynthesis in vitro by flavonoid baicalein from Scutellaria baicalensis georgy roots: I.G. Butenko, et al.; Agents Actions 39 Spec No, C49 (1993), Abstract;
Biliary excretion of metabolites of baicalin and baicalein in rats: K. Abe, et al.; Chem. Pharm. Bull. 38, 209 (1990), Abstract;
Inhibition of reverse transcriptase activity by a flavonoid compound, 5,6,7-trihydroxyflavone: K. Ono, et al.; BBRC 160, 982 (1989), Abstract;
Specific action of the lipoxygenase pathway in mediating angiotensin II- induced aldosterone synthesis in isolated adrenal glomerulosa cells: J.L. Nadler, et al.; J. Clin. Invest. 80, 1763 (1987), Abstract;
Selective inhibition of platelet lipoxygenase by baicalein: K. Sekiya & H. Okuda; BBRC 105, 1090 (1982), Abstract;

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