Replaces Prod. #: ALX-550-222
Cytochrome P-450 inhibitor. Inhibits cytochrome P-450-dependent arachidonate metabolism (90% at 50 µM). Calcium antagonist. Blocks glibenclamide-sensitive K+ channels (IC50=4.4mM). Inhibits platelet thromboxane synthesis and stimulates endothelial cell prostacyclin production. Potentiates the effects of many drugs in vivo.
Product Details
| Alternative Name: | Proadifen |
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| Formula: | C23H31NO2 . HCl |
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| MW: | 390.0 |
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| CAS: | 62-68-0 |
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| Purity: | ≥95% (TLC) |
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| Identity: | Determined by 1H-NMR and MS. |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in water (25mg/ml) or 100% ethanol. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Store, as supplied , at room temperature for up to 1 year. |
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| Handling: | Hygroscopic. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Inhibition by SKF 525A and quinacrine of endogenous glibenclamide-sensitive K+ channels in follicle-enclosed Xenopus oocytes: H. Sakuta & I. Yoneda; Eur. J. Pharmacol.
252, 117 (1994),
Abstract;
Subcellular localization and characterization of neuronal nitric oxide synthase: M. Hecker et al.; J. Neurochem.
62, 1524 (1994),
Abstract;
Inhibitors of cytochrome P-450 attenuate the myogenic response of dog renal arcuate arteries: K. Kauser et al.; Circ. Res.
68, 1154 (1991),
Abstract;
Effect of SKF 525A on the release of nitric oxide and prostacyclin from endothelial cells: D.D. Rees et al.; Eur. J. Pharmacol.
150, 149 (1988),
Abstract;
Defining the active site of cytochrome P-450: the crystal and molecular structure of an inhibitor, SKF-525A: M. Rossi et al.; Carcinogenesis
8, 881 (1987),
Abstract;
Stimulation of vascular prostacyclin by SKF 525-A (proadifen) and related compounds: J.M. Boeynaems et al.; Biochem. Pharmacol.
36, 1637 (1987),
Abstract;
Cytochrome P450-dependent arachidonate metabolism in renomedullary cells: formation of Na+K+-ATPase inhibitor: M.A. Carroll et al.; J. Hypertens. Suppl.
4, S33 (1986),
Abstract;
Prostacyclin-stimulating drugs: new prospects: J.M. Boeynaems et al.; Prostaglandins
32, 145 (1986),
Abstract;
Inhibition of mitochondrial oxidative metabolism by SKF-525A in intact cells and isolated mitochondria: T. Galeotti et al.; Biochem. Pharmacol.
32, 3285 (1983),
Abstract;
Stereoselective and calcium-dependent contractile effects of narcotic antagonist analgesics in the vascular smooth muscle of the rat: C.H. Lee & B.A. Berkowitz; J. Pharmacol. Exp. Ther.
198, 347 (1976),
Abstract;
Heterogeneity of cytochrome P-450 in rat liver microsomes: selective interaction of metyrapone and SKF 525-A with different fractions of microsomal cytochrome P-450: H. Grasdalen et al.; FEBS Lett.
60, 294 (1975),
Abstract;
The effects of beta-diethylaminoethyl-diphenylpropylacetate (SKE 525-A) on biological membranes. I. SKF 525-A-induced stabilization of human erythrocytes: I.P. Lee et al.; Biochem. Pharmacol.
17, 1671 (1968),
Abstract;
Effects of 2-diethylaminoethyl 2,2-diphenylpentanoate (SKF 525A) on insecticidal potency: P.S. Hewlett et al.; Nature
192, 1273 (1961),
Abstract;
