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SKF-525A . HCl

Cytochrome P450 inhibitor
 
BML-EI105-0250 250 mg 85.00 USD
 
BML-EI105-1000 1 g 247.00 USD
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Replaces Prod. #: ALX-550-222

Cytochrome P-450 inhibitor. Inhibits cytochrome P-450-dependent arachidonate metabolism (90% at 50 µM). Calcium antagonist. Blocks glibenclamide-sensitive K+ channels (IC50=4.4mM). Inhibits platelet thromboxane synthesis and stimulates endothelial cell prostacyclin production. Potentiates the effects of many drugs in vivo

Product Specification

Alternative Name:Proadifen
 
Formula:C23H31NO2 . HCl
 
MW:390.0
 
CAS:62-68-0
 
Purity:≥95% (TLC)
 
Identity:Determined by 1H-NMR and MS.
 
Appearance:White to off-white solid.
 
Solubility:Soluble in water (25mg/ml) or 100% ethanol.
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Store, as supplied , at room temperature for up to 1 year.
 
Handling:Hygroscopic.
 
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Product Literature References

Inhibition by SKF 525A and quinacrine of endogenous glibenclamide-sensitive K+ channels in follicle-enclosed Xenopus oocytes: H. Sakuta & I. Yoneda; Eur. J. Pharmacol. 252, 117 (1994), Abstract;
Subcellular localization and characterization of neuronal nitric oxide synthase: M. Hecker et al.; J. Neurochem. 62, 1524 (1994), Abstract;
Inhibitors of cytochrome P-450 attenuate the myogenic response of dog renal arcuate arteries: K. Kauser et al.; Circ. Res. 68, 1154 (1991), Abstract;
Effect of SKF 525A on the release of nitric oxide and prostacyclin from endothelial cells: D.D. Rees et al.; Eur. J. Pharmacol. 150, 149 (1988), Abstract;
Defining the active site of cytochrome P-450: the crystal and molecular structure of an inhibitor, SKF-525A: M. Rossi et al.; Carcinogenesis 8, 881 (1987), Abstract;
Stimulation of vascular prostacyclin by SKF 525-A (proadifen) and related compounds: J.M. Boeynaems et al.; Biochem. Pharmacol. 36, 1637 (1987), Abstract;
Cytochrome P450-dependent arachidonate metabolism in renomedullary cells: formation of Na+K+-ATPase inhibitor: M.A. Carroll et al.; J. Hypertens. Suppl. 4, S33 (1986), Abstract;
Prostacyclin-stimulating drugs: new prospects: J.M. Boeynaems et al.; Prostaglandins 32, 145 (1986), Abstract;
Inhibition of mitochondrial oxidative metabolism by SKF-525A in intact cells and isolated mitochondria: T. Galeotti et al.; Biochem. Pharmacol. 32, 3285 (1983), Abstract;
Stereoselective and calcium-dependent contractile effects of narcotic antagonist analgesics in the vascular smooth muscle of the rat: C.H. Lee & B.A. Berkowitz; J. Pharmacol. Exp. Ther. 198, 347 (1976), Abstract;
Heterogeneity of cytochrome P-450 in rat liver microsomes: selective interaction of metyrapone and SKF 525-A with different fractions of microsomal cytochrome P-450: H. Grasdalen et al.; FEBS Lett. 60, 294 (1975), Abstract;
The effects of beta-diethylaminoethyl-diphenylpropylacetate (SKE 525-A) on biological membranes. I. SKF 525-A-induced stabilization of human erythrocytes: I.P. Lee et al.; Biochem. Pharmacol. 17, 1671 (1968), Abstract;
Effects of 2-diethylaminoethyl 2,2-diphenylpentanoate (SKF 525A) on insecticidal potency: P.S. Hewlett et al.; Nature 192, 1273 (1961), Abstract;

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