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17-Octadecynoic acid

Fatty acid ω-hydroxylase inhibitor
 
BML-EI103-0010 10 mg 264.00 USD
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Potent suicide inhibitor of LTB4 ω-oxidase (IC50<5µM). Potent and selective inhibitor of fatty acid ω-hydroxylase (IC50<100 nM). Blocks biosynthesis of 20-HETE.

Product Specification

Formula:C18H32O2
 
MW:280.5
 
CAS:34450-18-5
 
Purity:≥98% (HPLC)
 
Appearance:White solid.
 
MeltingPoint:67-68°C
 
Solubility:Soluble in ethanol (25mg/ml) or DMSO (25mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
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Product Literature References

Effects of 17-octadecynoic acid, a suicide-substrate inhibitor of cytochrome P450 fatty acid omega-hydroxylase, on renal function in rats: A.-P. Zou, et al.; J. Pharmacol. Exp. Ther. 268, 474 (1994), Abstract;
Leukotriene B4 omega-hydroxylase in human polymorphonuclear leukocytes. Suicidal inactivation by acetylenic fatty acids: S. Shak, et al.; J. Biol. Chem. 260, 13023 (1985), Abstract; Full Text

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