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(±)5,6-Epoxyeicosa-8Z,11Z,14Z-trienoic acid

Potent vasodilator; stimulates insulin release
 
BML-EE56-1000 1 mg 830.00 USD
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Replaces Prod. #: ALX-340-059

Mobilizes Ca2+ in anterior pituitary cells. Stimulates insulin release from rat pancreatic islets. Potent stimulator of prolactin secretion. Potent vasodilator in the intestinal and cerebral microcirculation and in bovine coronary arteries. Endogenous TRPV4 agonist (Ki=150nM). Mediates angiotensin-induced natriuresis. Metabolized by cyclooxygenase.

Product Specification

Formula:C20H32O3
 
MW:320.5
 
Source:Synthetic.
 
CAS:81246-84-6.
 
Concentration:50µg/ml
 
Formulation:Liquid. Solution in ethanol.
 
Purity:≥90% (remainder hydroxylactone)
 
Solubility:50mg/ml soluble in 100% ethanol, DMSO or dimetyl formamide; slightly soluble in PBS, pH 7.2 (1mg/ml).
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-80°C
 
Use/Stability:For experiments with cells or tissues, aliquots of ethanol solutions may be added directly to aqueous media.
 
Handling:Protect from air. After opening, prepare aliquots and store at -80°C.
 
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Product Literature References

Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels: H. Watanabe, et al.; Nature 424, 434 (2003), Abstract;
M. Romero, et al.; Adv. Prostagland. Thromboxane Leukotriene Res. 21, 205 (1990),
M. Rosolowski, et al.; Adv. Prostagland. Thromboxane Leukotriene Res. 21, 213 (1990),
Dilation of cerebral arterioles by cytochrome P-450 metabolites of arachidonic acid: E.F. Ellis, et al.; Am. J. Physiol. 259, H1171 (1990), Abstract;
Epoxy derivatives of arachidonic acid are potent stimulators of prolactin secretion: J.R. Cashman, et al.; Neuroendocrinology 46, 246 (1987), Abstract;
Intestinal vasodilation by epoxyeicosatrienoic acids: arachidonic acid metabolites produced by a cytochrome P450 monooxygenase: K.G. Proctor, et al.; Circ. Res. 60, 50 (1987), Abstract;
5,6-Epoxyeicosatrienoic acid mobilizes Ca2+ in anterior pituitary cells: G. Snyder, et al.; BBRC 139, 1188 (1986), Abstract;
Epoxyeicosatrienoic acids stimulate glucagon and insulin release from isolated rat pancreatic islets: J.R. Falck, et al.; BBRC 114, 743 (1983), Abstract;

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