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FrPbAII

Selective inhibitor of GABA and glycine uptake
 
BML-EA150-0005 5 mg 278.00 USD
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FrPbAII is a component of the Parawixia bistriata spider venom. It has been shown to be a selective inhibitor of GABA and glycine uptake (IC50=65µM and 62µM respectively) with little or no effect on monoamine or glutamate transporters. It produces neuroprotective effects in a rat retinal ischemia/reperfusion model displaying remarkable reduction in cell death. It also abolishes convulsive tonic-clonic seizures induced by bicuculline (Prod. No. BML-EA149) in rats. Active in vivo. Crosses the blood-retina barrier.

Product Specification

Alternative Name:L-2-Amino-5-ureidopentanamide
 
Formula:C6H14N4O2 . HCl
 
MW:210.7
 
Purity:≥98% (NMR)
 
Appearance:Off-white solid.
 
Solubility:Soluble in water (>25mg/ml), DMSO (10mg/ml) or ethanol (25mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
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