FrPbAII - Enzo Life Sciences

BML-EA150

Revised 01-Feb-10

FrPbAII
SYNONYMS	L-2-Amino-5-ureidopentanamide
PRODUCT LINE	Neurobiology
PRODUCT CATEGORY	GABA Transporters / Related Products

Ordering Information

Product Numbers:	Format:	Size:	Unit Price:	Quantity:	Add To Cart
BML-EA150-0005		5 mg	257.00 USD

Product Specification

FORMULA:	C₆H₁₄N₄O₂ . HCl
MW:	210.7
PURITY:	≥98% (NMR)
APPEARANCE:	Off-white solid.
SOLUBILITY:	Soluble in water (>25mg/ml), DMSO (10mg/ml) or ethanol (25mg/ml).
SHIPPING:	SHIPPED ON BLUE ICE
LONG TERM STORAGE:	-20°C

Product Description

FrPbAII is a component of the Parawixia bistriata spider venom. It has been shown to be a
selective inhibitor of GABA and glycine uptake (IC₅₀=65µM and 62µM respectively) with little or no effect on monoamine or glutamate transporters. It produces neuroprotective effects in a rat retinal ischemia/reperfusion model displaying remarkable reduction in cell death. It also abolishes convulsive tonic-clonic seizures induced by bicuculline (Prod. No. BML-EA149) in rats. Active in vivo. Crosses the blood-retina barrier.

General Information