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L-trans-Pyrrolidine-2,4-dicarboxylic acid

Glutamate transporter inhibitor
 
BML-EA139-0025 25 mg 445.00 USD
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Potent and selective glutamate uptake inhibitor.

Product Specification

Formula:C6H9NO4
 
MW:159.1
 
CAS:64769-66-0
 
Purity:≥98% (HPLC)
 
Identity:Determined by 1H-NMR and MS.
 
Appearance:White solid.
 
Solubility:Soluble in water (10 mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
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Product Literature References

Comparison of Na+-dependent glutamate transport activity in synaptosomes, C6 glioma, and Xenopus oocytes expressing excitatory amino acid carrier 1 (EAAC1): L. A. Dowd, et al.; Mol. Pharmacol. 49, 465 (1996), Abstract;
Effects of L-trans-pyrrolidine-2,4-dicarboxylate and L-threo-3-hydroxyaspartate on the binding of [3H]L-aspartate, [3H]alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA), [3H]DL-(E)-2-amino-4-propyl-5-phosphono-3-pentenoate (CGP 39653), [3H]6-cyano-7-nitroquinoxaline-2,3-dione (CNQX) and [3H]kainate studied by autoradiography in rat forebrain: V. J. Balcar, et al.; Neurochem. Int. 26, 155 (1995), Abstract;
L-trans-pyrrolidine-2,4-dicarboxylate and cis-1-aminocyclobutane-1,3-dicarboxylate behave as transportable, competitive inhibitors of the high-affinity glutamate transporters: R. Griffiths, et al.; Biochem. Pharmacol. 47, 267 (1994), Abstract;
Regional differences in the inhibition of L-glutamate and L-aspartate sodium-dependent high affinity uptake systems in rat CNS synaptosomes by L-trans-pyrrolidine-2,4-dicarboxylate, threo-3-hydroxy-D-aspartate and D-aspartate: A. D. Mitrovic & G. A. Johnston; Neurochem. Int. 24, 583 (1994), Abstract;
The neuronal and epithelial human high affinity glutamate transporter. Insights into structure and mechanism of transport: Y. Kanai, et al.; J. Biol. Chem. 269, 20599 (1994), Abstract; Full Text
Conformationally defined neurotransmitter analogues. Selective inhibition of glutamate uptake by one pyrrolidine-2,4-dicarboxylate diastereomer: R. J. Bridges, et al.; J. Med. Chem. 34, 717 (1991), Abstract;

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