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Phaclofen

GABAB receptor antagonist
 
BML-EA127-0005 5 mg 86.00 USD
 
BML-EA127-0025 25 mg 361.00 USD
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Replaces Prod. #: ALX-550-056

Selective GABAB receptor antagonist. Antagonizes the postsynaptic action of baclofen (Prod. No. BML-EA128).

Product Specification

Alternative Name:(±)-3-Amino-2-(4-chlorophenyl)-propylphosphomic acid
 
Formula:C9H13ClNO3P
 
MW:249.6
 
CAS:114012-12-3
 
Purity:≥98% (HPLC)
 
Identity:Determined by 1H-NMR and MS.
 
Appearance:White solid.
 
Solubility:Soluble in water, methanol or DMSO.
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months.
 
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Product Literature References

Effects of taurine on depolarization-evoked release of amino acids from rat cortical synaptosomes: Y. Kamisaki, et al.; Brain Res. 627, 181 (1993), Abstract;
gamma-Aminobutyric acid (GABA) autoreceptors in rat cerebral cortex and spinal cord represent pharmacologically distinct subtypes of the GABAB receptor: G. Bonanno & M. Raiteri; J. Pharmacol. Exp. Ther. 265, 765 (1993), Abstract;
A physiological role for GABAB receptors in the central nervous system: P. Dutar & R.A. Niccol; Nature 332, 156 (1988), Abstract;
Comparison of antagonism by phaclofen of baclofen induced hyperpolarizations and synaptically mediated late hyperpolarizing potentials recorded intracellularly from rat dorsolateral septal neurons: H. Hasuo & J.P. Gallagher; Neurosci. Lett. 86, 77 (1988), Abstract;
Phaclofen: a GABAB blocker reduces long-duration inhibition in the neocortex: G. Karlsson, et al.; Eur. J. Pharmacol. 148, 485 (1988), Abstract;
Phaclofen: a peripheral and central baclofen antagonist: D.I. Kerr, et al.; Brain Res. 405, 150 (1987), Abstract;

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