Phaclofen

GABA_B receptor antagonist



BML-EA127-0005	5 mg	74.00 USD

BML-EA127-0025	25 mg	310.00 USD

Replaces Prod. #: ALX-550-056

Selective GABA_B receptor antagonist. Antagonizes the postsynaptic action of baclofen (Prod. No. BML-EA128).

Product Specification

Formula:	C₉H₁₃ClNO₃P

MW:	249.6

Purity:	≥98%

Appearance:	White solid.

CAS:	114012-12-3

Solubility:	Soluble in water, methanol or DMSO.

Long Term Storage:	Ambient

Use/Stability:	Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months.

Background / Technical Information:	Please click here for the comprehensive product datasheet.

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Product Literature References

Effects of taurine on depolarization-evoked release of amino acids from rat cortical synaptosomes: Y. Kamisaki et al.; Brain Res. 627, 181 (1993), Abstract;

gamma-Aminobutyric acid (GABA) autoreceptors in rat cerebral cortex and spinal cord represent pharmacologically distinct subtypes of the GABAB receptor: G. Bonanno & M. Raiteri; J. Pharmacol. Exp. Ther. 265, 765 (1993), Abstract;

A physiological role for GABAB receptors in the central nervous system: P. Dutar & R.A. Niccol; Nature 332, 156 (1988), Abstract;

Comparison of antagonism by phaclofen of baclofen induced hyperpolarizations and synaptically mediated late hyperpolarizing potentials recorded intracellularly from rat dorsolateral septal neurons: H. Hasuo & J.P. Gallagher; Nrurosci. Lett. 86, 77 (1988), Abstract;

Phaclofen: a GABAB blocker reduces long-duration inhibition in the neocortex: G. Karlsson et al.; Eur. J. Pharmacol. 148, 485 (1988), Abstract;

Phaclofen: a peripheral and central baclofen antagonist: D.I. Kerr et al.; Brain Res. 405, 150 (1987), Abstract;