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6,7-Dinitroquinoxaline-2,3-dione

AMPA/kainate receptor antagonist
 
BML-EA116-0010 10 mg 55.00 USD
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Replaces Prod. #: ALX-550-045

Potent, competitive kainate/quisqualate (non-NMDA) receptor antagonist.

Product Specification

Formula:C8H4N4O6
 
MW:252.1
 
CAS:2379-57-9
 
Purity:≥98% (HPLC)
 
Identity:Determined by 1H-NMR and MS.
 
Appearance:Pale yellow solid.
 
Solubility:Soluble in DMSO (10mg/ml), acetone or methanol.
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Store, as supplied, at room temperature for up to 1 year. Store solutions at 0-4°C for up to 3 months.
 
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Product Literature References

Stereochemistry of quinoxaline antagonist binding to a glutamate receptor investigated by Fourier transform infrared spectroscopy: D.R. Madden, et al.; J. Biol. Chem. 276, 37821 (2001), Abstract;
Disulfide bonding and cysteine accessibility in the alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor subunit GluRD. Implications for redox modulation of glutamate receptors: R. Abele, et al.; J. Biol. Chem. 273, 25132 (1998), Abstract;
6,7-Dichloroquinoxaline-2,3-dione is a competitive antagonist specific to strychnine-insensitive [3H]glycine binding sites on the N-methyl-D-aspartate receptor complex: K. Ogita & Y. Yoneda; J. Neurochem. 54, 699 (1990), Abstract;
Noncompetitive excitatory amino acid receptor antagonists: D. Lodge & K.M. Johnson; Trends Pharmacol. Sci. 11, 81 (1990), Abstract;
Abolition of the NMDA-mediated responses by a specifc glycine antagonist, 6,7-dichlorquinocaline-2,3-dione (DCQX): Y. Yoneda & K. Ogita; Biochem. Biophys. Res. Commun. 164, 841 (1989), Abstract;
Excitatory amino acid receptors in the  vertebrate central nervous system: G.L. Collingridge & R.A. Lester; Pharmacol. Rev. 41, 143 (1989), Abstract;
Selectivity of quinoxalines and kynurenines as antagonists of the glycine site on N-methyl-D-aspartate receptors.: N.W. Kleckner & R. Dingledine; Mol. Pharmacol. 36, 430 (1989), Abstract;
Contributions of quisqualate and NMDA receptors to the induction and expression of LTP: D. Muller, et al.; Science 242, 1694 (1988), Abstract;
Quinoxalinediones: potent competitive non-NMDA glutamate receptor antagonists: T. Honoré, et al.; Science 241, 701 (1988), Abstract;

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