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1α,25-Dihydroxyvitamin D3

Ultra-high purity
 
BML-DM200-0050 50 µg 199.00 USD
 
BML-DM200-1000 1 mg 1,872.00 USD
Do you need bulk/larger quantities?
 
Replaces Prod. #: ALX-460-032

1α,25-Dihydroxyvitamin D3 is the active hormonal form of vitamin D. It inhibits proliferation and induces differentiation of a variety of cells including osteoclasts, HL-60 cells. It is a central regulator of bone and calcium homeostasis. A polymorphism in the vitamin D receptor gene has been linked to a genetic predisposition to osteoporosis. It inhibits proliferation and induces differentiation of a variety of cells including osteoclasts, keratinocytes, HL-60 cells vascular smooth muscle cells and bone marrow macrophage precursors. It can activate signal transduction pathways that include hydrolysis of phosphatidylcholine and formation of diacylglycerol in chick myoblasts, and activation of Raf kinase in rat hepatic primary cells and 3T3 fibroblasts. It regulates c-myc protooncogene transcription, interleukin-8 expression, induction of cyclooxygenase, and directly activates protein kinase C at physiological concentrations (EC50=16 nM). Up-regulates RANKL level and down-regulates OPG level.

Product Specification

Alternative Name:1α,25-Dihydroxycholecalciferol, Calcitriol
 
Formula:C27H44O3
 
MW:416.6
 
Source:Synthetic.
 
CAS:32222-06-3
 
Purity:≥99% (HPLC)
 
Appearance:White solid.
 
Solubility:Soluble in DMSO, 100% ethanol,  ethyl acetate, tetrahydrofuran, chloroform or acetone. Evaporative loss of solvent may occur during storage and handling of the dissolved product. If necessary, exact concentration may be redetermined spectrophotometrically
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-80°C
 
Handling:Protect from light. For maximum stability, store solid in the dark under an inert gas such as argon. Store dissolved product in the dark in a tightly sealed container.
 
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Product Literature References

Concerted effects of heterogeneous nuclear ribonucleoprotein C1/C2 to control vitamin D-directed gene transcription and RNA splicing in human bone cells: R. Zhou, et al.; Nucleic Acids Res. 45, 606 (2017), Application(s): Cell culture for analysis of 25OHD metabolism by MG63 cells, Abstract; Full Text
Characterization of osteoarthritic human knees indicates potential sex differences: Q. Pan, et al. ; Biol. Sex Differ. 7, 27 (2016), Application(s): Cell culture, Abstract; Full Text
Eldecalcitol (ED-71), an Analog of 1α, 25-dihydroxy Vitamin D3 as a Potential Anti-cancer Agent for Oral Squamous Cell Carcinomas : T. Shintani, et al. ; J. Steroid Biochem Mol. Biol. 164, 79 (2016), Application(s): Cell Culture, Abstract;
Potential mechanisms underlying ectodermal differentiation of Wharton's jelly mesenchymal stem cells: S. Jadalannagari, et al.; Biochem. Biophys. Res. Commun. 478, 831 (2016), Application(s): MSC seeding onto scaffolds, Abstract;
Excess 25-hydroxyvitamin D3 exacerbates tubulointerstitial injury in mice by modulating macrophage phenotype: Y. Kusunoki, et al.; Kidney Int. 88, 1013 (2015), Application(s): Subcutaneous injection into mouse, Abstract;
Regulation of Osteoblast Differentiation by Acid-Etched and/or Grit-Blasted Titanium Substrate Topography Is Enhanced by 1,25(OH)2D3 in a Sex-Dependent Manner: R. Olivares-Navarrete, et al.; BioMed Res. Int. 2015, Article ID 365014 (2015), Application(s): Cell Culture, Abstract; Full Text
New insights on membrane mediated effects of 1α,25-dihydroxy vitamin D3 signaling in the musculoskeletal system: M. Doroudi, et al.; Steroids 81, 81 (2014), Application(s): Cell culture, Abstract;
Vitamin D up-regulates the vitamin D receptor by protecting it from proteasomal degradation in human CD4+ T cells: M. Kongsbak, et al.; PLoS One 9, e96695 (2014), Abstract;
Ceramides stimulate caspase-14 expression in human keratinocytes: Y.J. Jiang, et al.; Exp. Dermatol. 22, 113 (2013), Abstract;
Expression and regulation of GPAT isoforms in cultured human keratinocytes and rodent epidermis: L. Biao, et al.; J. Lipid Res. 51, 3207 (2010), Abstract; Full Text
Direct activation of protein kinase C by 1 alpha,25-dihydroxyvitamin D3: S.J. Slater et al; J. Biol. Chem. 270, 6639 (1995), Abstract;
1,25-Dihydroxyvitamin D3 and rat vascular smooth muscle cell growth: E.P.M. Carthy et al.; Hypertension 13, 954 (1989), Abstract;
Self-induction of 1,25-dihydroxyvitamin D3 metabolism limits receptor occupancy and target tissue responsiveness: T.A. Reinhardt & R.L. Horst; J. Biol. Chem. 264, 15917 (1989), Abstract;
1,25-Dihydroxyvitamin D3 modulates bone marrow macrophage precursor proliferation and differentiation. Up-regulation of the mannose receptor: D.R. Clohisy et al.; J. Biol. Chem. 262, 15922 (1987), Abstract;
H.F. De Luca & H.K. Schnoes; Annu. Rep. Med. Chem. 19, 179 (1984),
1,25-Dihydroxyvitamin D3-induced differentiation in a human promyelocytic leukemia cell line (HL-60): receptor-mediated maturation to macrophage-like cells: D.J. Mangelsdorf et al; J. Cell. Biol. 98, 391 (1984), Abstract;
1,25-dihydroxycholecalciferol: a potent stimulator of bone resorption in tissue culture: L.G. Raisz et al.; Science 175, 768 (1972), Abstract;
A rapidly acting metabolite of vitamin D3: M.R. Haussler et al.; PNAS 68, 177 (1971), Abstract;

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