1α,25-Dihydroxyvitamin D3

Ultra-high purity



BML-DM200-0050	50 µg	170.00 USD

BML-DM200-1000	1 mg	1'704.00 USD

Replaces Prod. #: ALX-460-032

1α,25-Dihydroxyvitamin D₃ is the active hormonal form of vitamin D. It inhibits proliferation and induces differentiation of a variety of cells including osteoclasts, HL-60 cells. It is a central regulator of bone and calcium homeostasis. A polymorphism in the vitamin D receptor gene has been linked to a genetic predisposition to osteoporosis. It inhibits proliferation and induces differentiation of a variety of cells including osteoclasts, keratinocytes, HL-60 cells vascular smooth muscle cells and bone marrow macrophage precursors.

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Product Specification

Alternative Name:	1α,25-Dihydroxycholecalciferol, Calcitriol

Formula:	C₂₇H₄₄O₃

MW:	416.6

Purity:	≥99% (HPLC)

Appearance:	White solid

CAS:	32222-06-3

Solubility:	Soluble in DMSO, 100% ethanol, ethyl acetate, tetrahydrofuran, chloroform or acetone. Evaporative loss of solvent may occur during storage and handling of the dissolved product. If necessary, exact concentration may be redetermined spectrophotometrically in ethanol solution (λmax=264 nm; ε = 19,000 M^-1cm^-1; 2.2μg/ml yields A₂₆₄=0.10).

Long Term Storage:	-80°C

Use/Stability:	For maximum stability, store solid in the dark under an inert gas such as argon. Store dissolved product in the dark in a tightly sealed container.

Hazard:	MAY BE TERATOGENIC. VERY TOXIC.

Handling:	Protect from light.

Background / Technical Information:	Please click here for the comprehensive product datasheet.

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Product Literature References

Direct activation of protein kinase C by 1 alpha,25-dihydroxyvitamin D3: S.J. Slater et al; J. Biol. Chem. 270, 6639 (1995), Abstract;

1,25-Dihydroxyvitamin D3 and rat vascular smooth muscle cell growth: E.P.M. Carthy et al.; Hypertension 13, 954 (1989), Abstract;

Self-induction of 1,25-dihydroxyvitamin D3 metabolism limits receptor occupancy and target tissue responsiveness: T.A. Reinhardt & R.L. Horst; J. Biol. Chem. 264, 15917 (1989), Abstract;

1,25-Dihydroxyvitamin D3 modulates bone marrow macrophage precursor proliferation and differentiation. Up-regulation of the mannose receptor: D.R. Clohisy et al.; J. Biol. Chem. 262, 15922 (1987), Abstract;

H.F. De Luca & H.K. Schnoes; Annu. Rep. Med. Chem. 19, 179 (1984),

1,25-Dihydroxyvitamin D3-induced differentiation in a human promyelocytic leukemia cell line (HL-60): receptor-mediated maturation to macrophage-like cells: D.J. Mangelsdorf et al; J. Cell. Biol. 98, 391 (1984), Abstract;

1,25-dihydroxycholecalciferol: a potent stimulator of bone resorption in tissue culture: L.G. Raisz et al.; Science 175, 768 (1972), Abstract;

A rapidly acting metabolite of vitamin D3: M.R. Haussler et al.; PNAS 68, 177 (1971), Abstract;