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Clozapine

Dopamine receptor and serotonin receptor antagonist
 
BML-D107-0050 50 mg 65.00 USD
 
BML-D107-0500 500 mg 381.00 USD
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Replaces Prod. #: ALX-550-088

Dopamine D4 and D2 receptor antagonist. High affinity for the cloned rat dopamine D4 receptor (Ki<20nM). Atypical neuroleptic agent. Antagonist at 5HT2A, 5HT2C, 5HT3, 5HT6 and 5HT7 receptors.

Product Specification

Alternative Name:8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e]-[1,4]diazepine
 
Formula:C18H19ClN4
 
MW:326.8
 
CAS:5786-21-0
 
MI:14: 2423
 
RTECS:HP1750000
 
Purity:≥99% (Assay)
 
Identity:Determined by IR.
 
Appearance:Yellow crystalline powder.
 
Solubility:Soluble in DMSO (30mg/ml) or dilute aqueous acid.
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
ALX-550-088
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ALX-550-088

Product Literature References

Small molecule inhibitors of the Candida albicans budded-to-hyphal transition act through multiple signaling pathways: J. Midkiff, et al.; PLoS One 6, e25395 (2011), Abstract; Full Text
D4 dopamine receptor binding affinity does not distinguish between typical and atypical antipsychotic drugs: B.L. Roth, et al.; Psychopharmacology 120, 365 (1995), Abstract;
Interaction of clozapine with the histamine H3 receptor in rat brain: A.A. Rodrigues, et al.; Br. J. Pharmacol. 114, 1523 (1995), Abstract;
Role of serotonin in the action of atypical antipsychotic drugs: H.Y. Meltzer; Clin. Neurosci. 3, 64 (1995), Abstract;
5-HT1C receptor-mediated phosphoinositide hydrolysis in the rat choroid plexus after chronic treatment with clozapine: M. Kuoppamaki, et al.; Eur. J. Pharmacol. 255, 91 (1994), Abstract;
Clozapine is a potent and selective muscarinic M4 receptor agonist: S.H. Zorn, et al.; Eur. J. Pharmacol. 269, R1 (1994), Abstract;
Clozapine and N-desmethylclozapine are potent 5-HT1C receptor antagonists: M. Kuoppamaki, et al.; Eur. J. Pharmacol. 245, 179 (1993), Abstract;
Cloning of the gene for a human dopamine D4 receptor with high affinity for the antipsychotic clozapine: H.H. Van Tol, et al.; Nature 350, 610 (1991), Abstract;
The involvement of dopamine D1 and D2 receptors in the effects of the classical neuroleptic haloperidol and the atypical neuroleptic clozapine: B.A. Ellenbroek, et al.; Eur. J. Pharmacol. 196, 103 (1991), Abstract;
Binding of typical and atypical antipsychotics to 5-HT1C and 5-HT2 sites: clozapine potently interacts with 5-HT1C sites: H. Canton, et al.; Eur. J. Pharmacol. 191, 93 (1990), Abstract;

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