Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

ZK-756326

CCR8 activator
 
BML-CX101-0010 10 mg 105.00 USD
 
BML-CX101-0050 50 mg 434.00 USD
Do you need bulk/larger quantities?
 
Novel small molecule agonist at the CCR8 chemokine receptor (EC50=254nM) with no activity at CCR1, CCR2B, CCR4, CCR5, CXCR2, CXCR3 or CXCR4. Dose dependently increases intracellular calcium and stimulates extracellular acidification in cells expressing human CCR8. Murine CCR8-expressing cells underwent chemotaxis on exposure to this agonist. Inhibits HIV fusion of cells expressing CD4 and CCR8. Small molecule CCR8 agonists represent useful tools for exploring CCR8 biology especially in experiments where the use of the natural protein agonist is impractical.

Product Specification

Alternative Name:2-[2-[4-[(3-Phenoxyphenyl)methyl]-1-piperazinyl]ethoxy]ethanol dihydrochloride
 
Formula:C21H28N2O3 . 2HCl
 
MW:356.4 . 73.0
 
CAS:874911-96-3
 
Purity:≥98% (TLC)
 
Appearance:White solid.
 
Solubility:Soluble in water (5 mg/ml) or DMSO (4 mg/ml).
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Use/Stability:Store, as supplied, at room temperature for up to one year.  Store solutions at -20°C for up to 3 months.
 
BML-CX101 Structure
Please mouse over
BML-CX101 Structure

Product Literature References

Molecular interaction of a potent nonpeptide agonist with the chemokine receptor CCR8.: P.A. Jensen, et al.; Mol. Pharmacol. 72, 327 (2007), Abstract;
Identification and Characterization of a Potent, Selective Nonpeptide Agonist of the CC Chemokine Receptor CCR8 : C.A. Haskell, et al. ; Mol. Pharmacol. 69, 309 (2006), Abstract; Full Text

Product Toolbox

PRODUCT RESOURCES

Datasheet
MSDS
Certificate of Analysis

RELATED PRODUCTS

By target:
Chemokine receptor
By biological activity:
Chemokine receptor Ligand
Chemokine receptor Activator
By catalog section:

PRODUCT SUPPORT

FAQs
Technical Service
Customer Service

Recommend this page

 
For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2017 Enzo Life Sciences, Inc.,