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Shikonin

Inhibits angiogenesis
 
BML-CT115-0010 10 mg 63.00 USD
 
BML-CT115-0050 50 mg 223.00 USD
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Shikonin inhibits TNF-α- and B6 melanoma-induced angiogenesis in mice. It blocks expression of integrin αvβ3 and inhibits endothelial cell proliferation and migration in vitro.

Product Specification

Formula:C16H16O5
 
MW:288.3
 
Source:Shikonin is a napthoquinone isolated from the roots of Lithospermum erythrorhizon; a component of the traditional Chinese herbal remedy Shiunko.
 
CAS:517-89-5
 
Purity:≥98% (HPLC)
 
Identity:Determined by NMR and MS.
 
Appearance:Red crystalline solid.
 
Solubility:Soluble in DMSO.
 
Shipping:Ambient
 
Long Term Storage:+4°C
 
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Product Literature References

Nephropreventive Effect of Shikonin on Murine LPS-induced Septic Acute Kidney: M. Kawara, et al.; J. Clin. Exp. Nephrol. 1, 19 (2016), Application(s): In vivo murine administration, Full Text
Cytotoxicity of natural products and derivatives towards MCF-7 cell monolayers and cancer stem-like mammospheres: E.J. Seo, et al.; Phytomedicine 22, 438 (2015), Application(s): Flow Cytometry, Abstract;
A naphthoquinone derivative, shikonin, has insulin-like actions by inhibiting both phosphatase and tensin homolog deleted on chromosome 10 and tyrosine phosphatases: K. Nigorikawa, et al.; Mol. Pharmacol. 70, 1143 (2006), Abstract; Full Text
p53-mediated cell cycle arrest and apoptosis induced by shikonin via a caspase-9-dependent mechanism in human malignant melanoma A375-S2 cells: Z. Wu, et al.; J. Pharmacol. Sci. 94, 166 (2004), Abstract;
Shikonin, an ingredient of Lithospermum erythrorhizon, inhibits angiogenesis in vivo and in vitro: T. Hisa, et al.; Anticancer Res. 18, 783 (1998), Abstract;

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