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Thiolutin

RNA polymerase inhibitor
 
BML-CT107-0001 1 mg 108.00 USD
 
BML-CT107-0005 5 mg 432.00 USD
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Replaces Prod. #: ALX-380-200

Sulfur containing antibiotic. Potent inhibitor of bacterial and yeast RNA polymerases. Inhibits mRNA chain elongation. Inhibits adhesion of endothelial cells (HUVECs) to vitronectin (IC50=0.83 µM) thereby inhibiting tumor cell-induced angiogenesis in vivo. Inhibits transcription in C. albicans. Inhibits microbiological growth in beer. Active against soil borne pathogens.

Product Specification

Alternative Name:6-(Acetamido)-4-methyl-1,2-dithiolo[4,3-b]-pyrrol-5(4H)-one
 
Formula:C8H8N2O2S2
 
MW:228.3
 
Source:Isolated from Streptomyces luteosporeus
 
CAS:87-11-6
 
Purity:≥95% (HPLC, TLC)
 
Appearance:Yellow crystalline solid.
 
Solubility:Soluble in DMSO (5mg/ml), very slightly soluble in water
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
BML-CT107 structure
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BML-CT107 structure

Product Literature References

Determination of mRNA half-lives in Candida albicans using thiolutin as a transcription inhibitor: B.W. Kebaara, et al.; Genome 49, 894 (2006), Abstract;
Genome-wide analysis of mRNA stability using transcription inhibitors and microarrays reveals posttranscriptional control of ribosome biogenesis factors: J. Grigull, et al.; Mol. Cell. Biol. 24, 5534 (2004), Abstract;
Thiolutin, an inhibitor of HUVEC adhesion to vitronectin, reduces paxillin in HUVECs and suppresses tumor cell-induced angiogenesis: K. Minamiguchi, et al.; Int. J. Cancer. 93, 307 (2001), Abstract;
The yeast heat shock response is induced by conversion of cells to spheroplasts and by potent transcriptional inhibitors: C.C. Adams; J. Bacteriol. 173, 7429 (1991), Abstract;
Activity of thiolutin against certain soil borne plant-pathogens: P.R. Deb & B.K. Dutta; Curr. Sci. 53, 659 (1984),
Cell wall synthesis regulation in Saccharomyces cerevisiae. Effect of RNA and protein inhibition: M.V. Elorza, et al.; Biochim. Biophys. Acta. 454, 263 (1976), Abstract;
In vivo effect of thiolutin on cell growth and macromolecular synthesis in Escherichia coli: G.G. Khachatourians & D.J. Tipper; Antimicrob. Agents Chemother. 6, 304 (1974), Abstract;
Inhibition of messenger ribonucleic acid synthesis in Escherichia coli by thiolutin: G.G. Khachatourians & D.J. Tipper; J. Bacteriol. 119, 795 (1974), Abstract;
Inhibition of yeast ribonucleic acid polymerases by thiolutin: D.J. Tipper, et al.; J. Bacteriol. 116, 245 (1973), Abstract;
The structures of thiolutin and aureothricin, antibiotics containing a unique pyrrolinonodithiole nucleus: W.D. Celmer & I.A. Solomons; JACS 77, 2861 (1955), Abstract;
Characterization of the antibiotic thiolutin and its relationship with aureothricin: W.D. Celmer, et al.; JACS 74, 6304 (1952), Abstract;

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