Replaces Prod. #: ALX-380-200
Sulfur containing antibiotic. Potent inhibitor of bacterial and yeast RNA polymerases. Inhibits mRNA chain elongation. Inhibits adhesion of endothelial cells (HUVECs) to vitronectin (IC50=0.83 µM) thereby inhibiting tumor cell-induced angiogenesis in vivo. Inhibits transcription in C. albicans. Inhibits microbiological growth in beer. Active against soil borne pathogens.
Product Details
Alternative Name: | 6-(Acetamido)-4-methyl-1,2-dithiolo[4,3-b]-pyrrol-5(4H)-one |
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Formula: | C8H8N2O2S2 |
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MW: | 228.3 |
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Source: | Isolated from Streptomyces luteosporeus |
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CAS: | 87-11-6 |
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Purity: | ≥95% (HPLC, TLC) |
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Appearance: | Yellow crystalline solid. |
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Solubility: | Soluble in DMSO (5mg/ml), very slightly soluble in water |
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Shipping: | Ambient Temperature |
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Long Term Storage: | -20°C |
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Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Determination of mRNA half-lives in Candida albicans using thiolutin as a transcription inhibitor: B.W. Kebaara, et al.; Genome
49, 894 (2006),
Abstract;
Genome-wide analysis of mRNA stability using transcription inhibitors and microarrays reveals posttranscriptional control of ribosome biogenesis factors: J. Grigull, et al.; Mol. Cell. Biol.
24, 5534 (2004),
Abstract;
Thiolutin, an inhibitor of HUVEC adhesion to vitronectin, reduces paxillin in HUVECs and suppresses tumor cell-induced angiogenesis: K. Minamiguchi, et al.; Int. J. Cancer.
93, 307 (2001),
Abstract;
The yeast heat shock response is induced by conversion of cells to spheroplasts and by potent transcriptional inhibitors: C.C. Adams; J. Bacteriol.
173, 7429 (1991),
Abstract;
Activity of thiolutin against certain soil borne plant-pathogens: P.R. Deb & B.K. Dutta; Curr. Sci. 53, 659 (1984),
Cell wall synthesis regulation in Saccharomyces cerevisiae. Effect of RNA and protein inhibition: M.V. Elorza, et al.; Biochim. Biophys. Acta.
454, 263 (1976),
Abstract;
In vivo effect of thiolutin on cell growth and macromolecular synthesis in Escherichia coli: G.G. Khachatourians & D.J. Tipper; Antimicrob. Agents Chemother.
6, 304 (1974),
Abstract;
Inhibition of messenger ribonucleic acid synthesis in Escherichia coli by thiolutin: G.G. Khachatourians & D.J. Tipper; J. Bacteriol.
119, 795 (1974),
Abstract;
Inhibition of yeast ribonucleic acid polymerases by thiolutin: D.J. Tipper, et al.; J. Bacteriol.
116, 245 (1973),
Abstract;
The structures of thiolutin and aureothricin, antibiotics containing a unique pyrrolinonodithiole nucleus: W.D. Celmer & I.A. Solomons; JACS
77, 2861 (1955),
Abstract;
Characterization of the antibiotic thiolutin and its relationship with aureothricin: W.D. Celmer, et al.; JACS
74, 6304 (1952),
Abstract;