Replaces Prod. #: ALX-350-119
Inhibitor of angiogenesis and endothelial cell proliferation. Specific inhibitor of methionine aminopeptidase type II (MetAP-II) by covalently modifying a conserved active-site histidine. Precursor to TNP-470. Exhibits antitumor activity in estrogen-induced pituitary adenoma. Antineoplastic. Anti-infective.
Product Details
| Alternative Name: | Fumidil B, Fumadil B, TNP-470 |
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| Formula: | C26H34O7 |
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| MW: | 458.5 |
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| Source: | Isolated from Aspergillus fumigatus. |
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| CAS: | 23110-15-8 |
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| MI: | 14: 4286 |
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| Purity: | ≥95% (TLC) |
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| Appearance: | Off-white to light yellow solid. |
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| Solubility: | Soluble in DMSO (25mg/ml) or diluted aqueous bases; slightly soluble in methanol or other alcoholic solvents; insoluble in water. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months at -20°C. Unstable in aqueous solutions with pH >9.0 or pH <5.0. |
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| Handling: | Protect from light and oxygen. Keep under inert gas. |
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| Technical Info/Product Notes: | Note: Product is not sterile. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
FGFR1/PI3K/AKT signaling pathway is a novel target for antiangiogenic effects of the cancer drug fumagillin (TNP-470): G.J. Chen, et al.; J. Cell Biochem.
101, 1492 (2007),
Abstract;
Fumagillin: an anti-infective as a parent molecule for novel angiogenesis inhibitors: B. Lefkove, et al.; Expert Rev. Anti Infect. Ther.
5, 573 (2007), Review,
Abstract;
Fumagillin treatment of hepatocellular carcinoma in rats: an in vivo study of antiangiogenesis: I.S. Sheen, et al.; World J. Gastroenterol.
11, 771 (2005),
Abstract;
Whirling disease of salmonid fish: life cycle, biology, and disease: M.A. Gilbert & W.O. Granath, Jr.; J. Parasitol.
89, 658 (2003),
Abstract;
Fumagillin treatment of intestinal microsporidiosis: J.M. Molina, et al.; N. Engl. J. Med.
346, 1963 (2002),
Abstract;
Molecular recognition of angiogenesis inhibitors fumagillin and ovalicin by methionine aminopeptidase 2: E.C. Griffith, et al.; PNAS
95, 15183 (1998),
Abstract;
The anti-angiogenic agent fumagillin covalently modifies a conserved active-site histidine in the Escherichia coli methionine aminopeptidase: W.T. Lowther, et al.; PNAS
95, 12153 (1998),
Abstract;
Full Text
The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2: N. Sin, et al.; PNAS
94, 6099 (1997),
Abstract;
Full Text
Inhibitory effects of fumagillin and its analogue TNP-470 on the function, morphology and angiogenesis of an oestrogen-induced prolactinoma in Fischer 344 rats: H. Stepien, et al.; J. Endocrinol.
150, 99 (1996),
Abstract;
Potent anti-angiogenic action of AGM-1470: comparison to the fumagillin parent: M. Kusaka, et al.; BBRC
174, 1070 (1991),
Abstract;
Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth: D. Ingber, et al.; Nature
348, 555 (1990),
Abstract;
Fumagillin (H-3), a new antibiotic with amebicidal properties: C.M. Mc, et al.; Science
113, 202 (1951),
Abstract;
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