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Fumagillin

Methionine aminopeptidase 2 inhibitor
 
BML-CT100-0001 1 mg 95.00 USD
 
BML-CT100-0005 5 mg 397.00 USD
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Replaces Prod. #: ALX-350-119

Inhibitor of angiogenesis and endothelial cell proliferation. Specific inhibitor of methionine aminopeptidase type II (MetAP-II) by covalently modifying a conserved active-site histidine. Precursor to TNP-470. Exhibits antitumor activity in estrogen-induced pituitary adenoma. Antineoplastic. Anti-infective.

Product Specification

Alternative Name:Fumidil B, Fumadil B, TNP-470
 
Formula:C26H34O7
 
MW:458.5
 
Source:Isolated from Aspergillus fumigatus.
 
CAS:23110-15-8
 
MI:14: 4286
 
Purity:≥95% (TLC)
 
Appearance:Off-white to light yellow solid.
 
Solubility:Soluble in DMSO (25mg/ml) or diluted aqueous bases; slightly soluble in methanol or other alcoholic solvents; insoluble in water.
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 1 year after receipt when stored at -20°C. Stock solutions are stable for up to 3 months at -20°C. Unstable in aqueous solutions with pH >9.0 or pH <5.0.
 
Handling:Protect from light and oxygen. Keep under inert gas.
 
Technical Info/Product Notes:Note: Product is not sterile.
 
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Product Literature References

FGFR1/PI3K/AKT signaling pathway is a novel target for antiangiogenic effects of the cancer drug fumagillin (TNP-470): G.J. Chen, et al.; J. Cell Biochem. 101, 1492 (2007), Abstract;
Fumagillin: an anti-infective as a parent molecule for novel angiogenesis inhibitors: B. Lefkove, et al.; Expert Rev. Anti Infect. Ther. 5, 573 (2007), Review, Abstract;
Fumagillin treatment of hepatocellular carcinoma in rats: an in vivo study of antiangiogenesis: I.S. Sheen, et al.; World J. Gastroenterol. 11, 771 (2005), Abstract;
Whirling disease of salmonid fish: life cycle, biology, and disease: M.A. Gilbert & W.O. Granath, Jr.; J. Parasitol. 89, 658 (2003), Abstract;
Fumagillin treatment of intestinal microsporidiosis: J.M. Molina, et al.; N. Engl. J. Med. 346, 1963 (2002), Abstract;
Molecular recognition of angiogenesis inhibitors fumagillin and ovalicin by methionine aminopeptidase 2: E.C. Griffith, et al.; PNAS 95, 15183 (1998), Abstract;
The anti-angiogenic agent fumagillin covalently modifies a conserved active-site histidine in the Escherichia coli methionine aminopeptidase: W.T. Lowther, et al.; PNAS 95, 12153 (1998), Abstract; Full Text
The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2: N. Sin, et al.; PNAS 94, 6099 (1997), Abstract; Full Text
Inhibitory effects of fumagillin and its analogue TNP-470 on the function, morphology and angiogenesis of an oestrogen-induced prolactinoma in Fischer 344 rats: H. Stepien, et al.; J. Endocrinol. 150, 99 (1996), Abstract;
Potent anti-angiogenic action of AGM-1470: comparison to the fumagillin parent: M. Kusaka, et al.; BBRC 174, 1070 (1991), Abstract;
Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth: D. Ingber, et al.; Nature 348, 555 (1990), Abstract;
Fumagillin (H-3), a new antibiotic with amebicidal properties: C.M. Mc, et al.; Science 113, 202 (1951), Abstract;

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MetAP2 (human), (recombinant) (HA-tag) 

Produced in insect cells. Recombinant, full-length (aa 1-478) methionine aminopeptidase 2 with an N-terminal hemagglutinin (HA) tag (YPYDVPDYA), cloned from human cDNA., ≥95% (SDS-PAGE) | Print as PDF
 
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