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Cytochrome P450 3A2 (rat) polyclonal antibody

 
BML-CR3320-0025 25 µl 108.00 USD
 
BML-CR3320-0100 100 µl 345.00 USD
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Product Specification

Alternative Name:CYP3A2
 
Host:Rabbit
 
Immunogen:Synthetic peptide corresponding to a portion of C-terminal rat CYP3A21.
 
UniProt ID:P05183
 
Species reactivity:Rat
 
Specificity:Recognizes rat CYP3A2. Not suitable for use on human tissue.
 
Applications:IHC (FS), IHC (PS), WB
 
Shipping:Shipped on Blue Ice
 
Long Term Storage:-20°C
 
Scientific Background:Members of the cytochrome P-450 3A (CYP3A) sub-family catalyze the 6β-hydroxylation of testosterone, and the metabolism of a number of drugs such as cyclosporin A (Prod. No. BML-A195), and warfarin. They are inducible by glucocorticoids such as dexamethasome (Prod. No. BML-EI126) and by macrolide antibiotics such as erythromycin and pregnenolone 16α-carbonitrile (U-14975, PCN) (Prod. No. BML- S620). Rat CYP3A1 and CPY3A2 share 89% sequence similarity at the amino acid level and are predominantly located in the liver, principally in the centrilobular region. PCN induces CYP3A1/2 gene expresion in regions of the liver.
 

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