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Leelamine

Pyruvate dehydrogenase kinase inhibitor
 
BML-CR114-0010 10 mg 76.00 USD
 
BML-CR114-0050 50 mg 302.00 USD
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Replaces Prod. #: ALX-550-522

Leelamine binds weakly to the CB1 receptor (Ki= 5 µM) and does not stimulate G-protein activity. It exhibits potent behavioural activity reminiscent of THC which are reversed by the CB1 antagonist SR141716A. Paradoxically it is also active in CB1 knockout mice indicating that other receptors or targets mediate its effects. Also inhibits pyruvate dehydrogenase kinase (IC50=9.5µM).

Product Specification

Alternative Name:Dehydroabietylamine
 
Formula:C20H31N . HCl
 
MW:321.9
 
CAS:1446-61-3
 
Purity:≥98% (TLC)
 
Appearance:White solid.
 
Solubility:Soluble in DMSO (>25mg/ml) or 100% ethanol (>25mg/ml). Sparingly soluble in dimethyl formamide.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Store as supplied, at -20°C, for up to 1 year. Store solutions at -20°C for up to 3 months.
 
550-522
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550-522

Product Literature References

W.A. Devane et al.; Proceedings of the Joint Meeting on Med. Chem. Slovenia Abstract PO030 (2007),
Triterpene and diterpene inhibitors of pyruvate dehydrogenase kinase (PDK): T.D. Aicher et al.; Bioorg. Med. Chem. Lett. 98, 2223 (1999), Abstract;

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