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GW-405833

Cannabinoid receptor ligand
 
BML-CR112-0010 10 mg 140.00 USD
 
BML-CR112-0050 50 mg 573.00 USD
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GW-405833 binds to both rat and human CB2 receptors where it acts as a partial agonist. It elicits potent and efficacious antihyperalgesic effects in rodent models of neuropathic, incisional and chronic inflammatory pain. Its antinociceptive properties are opioid independent. It displays anti-inflammatory effects in vivo.

Product Specification

Formula:C23H24Cl2N2O3
 
MW:447.4
 
CAS:180002-83-9
 
Purity:≥97% (HPLC)
 
Appearance:Off-white solid.
 
Solubility:Soluble in DMSO (15 mg/ml) or ethanol (5 mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
BML-CR112 structure
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BML-CR112 structure

Product Literature References

A role for cannabinoid receptors, but not endogenous opioids, in the antinociceptive activity of the CB2-selective agonist, GW405833: K.J. Valenzano, et al.; Neuropharmacology. 48, 658 (2005), Abstract;
A role for cannabinoid receptors, but not endogenous opioids, in the antinociceptive activity of the CB2-selective agonist, GW405833: G.T. Whitesides, et al.; Eur. J. Pharmacol. 528, 65 (2005), Abstract;
Cannabinoid CB2 receptor agonist activity in the hindpaw incision model of postoperative pain: C.J. LaBuda, et al.; Eur. J. Pharmacol. 527, 172 (2005), Abstract;
CB1 and CB2 cannabinoid receptors are implicated in inflammatory pain: N. Clayton, et al.; Pain 96, 253 (2002), Abstract;

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