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VDM-11

Anandamide transporter inhibitor
 
BML-CR111-0010 10 mg 59.00 USD
 
BML-CR111-0050 50 mg 250.00 USD
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Replaces Prod. #: ALX-340-046

Selective and potent inhibitor of the anandamide membrane transporter (AMT) (neuronal (C6 glioma cells): IC50=11µM; non-neuronal (rat RBL-2H3 cells): IC50=7.2µM) with negligible action at TRPV1 and weak action at CB1 receptor (CB1: Ki=5µM; CB2: Ki>5µM) and FAAH (IC50=3.7µM/ IC50>50µM (N18TG2 cell membranes).

Product Specification

Alternative Name:N-Arachidonoyl-4-hydroxy-2-methylaniline, N-(4-Hydroxy-2-methylphenyl)arachidonoylamide
 
Formula:C27H39NO2
 
MW:409.6
 
CAS:313998-81-1
 
Purity:≥98% (TLC)
 
Appearance:Tan oil.
 
Solubility:Soluble in DMSO (1.5mg/ml) or ethanol (1mg/ml).
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
 
Handling:Keep under inert gas.
 
340-046
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340-046

Product Literature References

Characterization of an anandamide degradation system in prostate epithelial PC-3 cells: synthesis of new transporter inhibitors as tools for this study: L. Ruiz-Llorente et al.; Br. J. Pharmacol. 141, 457 (2004), Abstract;
Endocannabinoids as physiological regulators of colonic propulsion in mice: L. Pinto, et al.; Gastroenterology 123, 227 (2002), Abstract;
Experimental parkinsonism alters endocannabinoid degradation: implications for striatal glutamatergic transmission: P. Gubellini, et al.; J. Neurosci. 22, 6900 (2002), Abstract;
Endocannabinoids control spasticity in a multiple sclerosis model: D. Baker, et al.; FASEB J. 15, 300 (2001), Abstract; Full Text
Exogenous anandamide protects rat brain against acute neuronal injury in vivo: M. van der Stelt, et al.; J. Neurosci. 21, 8765 (2001), Abstract;
The activity of anandamide at vanilloid VR1 receptors requires facilitated transport across the cell membrane and is limited by intracellular metabolism: L. De Petrocellis, et al.; J. Biol. Chem. 276, 12856 (2001), Abstract; Full Text
The activity of anandamide at vanilloid VR1 receptors requires facilitated transport across the cell membrane and is limited by intracellular metabolism: L. De Petrocellis, et al.; J. Biol. Chem. 276, 12856 (2001), Abstract;
Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: inhibitors of anandamide uptake with negligible capsaicin-like activity: L. De Petrocellis, et al.; FEBS Lett. 483, 52 (2000), Abstract;

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