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CP-55,940

Cannabinoid receptor ligand
 
BML-CR102-0005 5 mg 162.00 USD
 
BML-CR102-0025 25 mg 631.00 USD
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Replaces Prod. #: ALX-270-242

Cannabinoid CB1 and CB2 agonist which is more potent than δ9-THC. Kd’s for cloned/transfected CB1 and CB2: 2.6 & 3.7 nM. Has been reported to induce the immediate early gene Krox-24 in corpus striatum and cultured astrocytes. Stimulates proliferation of stimulated B-cells at low nM concentrations.

Product Specification

Formula:C24H40O3
 
MW:376.6
 
CAS:83002-04-4
 
Purity:≥98% (HPLC)
 
Identity:Determined by 1H-NMR and MS.
 
Appearance:White solid.
 
Solubility:Soluble in DMSO (4mg/ml) or ethanol.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Store, as supplied, for up to 1 year. Store solutions at -20°C for up to 3 months.
 
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Product Literature References

The central cannabinoid receptor (CB1) mediates inhibition of nitric oxide production by rat microglial cells: Y. Waksman et al.; J. Pharmacol. Exp. Ther. 288, 1357 (1999), Abstract;
Comparative receptor binding analyses of cannabinoid agonists and antagonists: B.F. Thomas et al.; J. Pharmacol. Exp. Ther. 285, 285 (1998), Abstract;
Cannabinoids enhance human B-cell growth at low nanomolar concentrations: J.M. Derocq et al.; FEBS Lett. 369, 177 (1995), Abstract;
Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors: C.C. Felder et al.; Mol. Pharmacol. 48, 443 (1995), Abstract;
Discriminative stimulus effects of CP 55,940 and structurally dissimilar cannabinoids in rats: J.L. Wiley et al.; Neuropharmacology 34, 669 (1995), Abstract;
Induction of the Krox 24 transcription factor in striosomes by a cannabinoid agonist: M. Glass & M. Dragunow ; Neuroreport 6, 241 (1995), Abstract;
Stimulation of cannabinoid receptor CB1 induces krox-24 expression in human astrocytoma cells: M. Bouaboula et al.; J. Biol. Chem. 270, 13973 (1995), Abstract;

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