Online Purchasing Account You are logged on as Guest. LoginRegister a New AccountShopping cart (Empty)
United States 

N(5)-(1-Iminoethyl)-L-ornithine . HCl

NOS inhibitor
 
BML-CN248-0010 10 mg 174.00 USD
 
BML-CN248-0050 50 mg 567.00 USD
Do you need bulk/larger quantities?
 
Replaces Prod. #: ALX-270-002

L-NIO is approximately 5 times more potent as an inhibitor of endothelial cell NO synthase than other arginine analogs such as L-NAME and L-NMMA. It inhibits NO production in endothelial cytosol (IC50=0.5µM), inhibits acetylcholine induced relaxation of rat aorta rings (IC50=2µM) and causes a dose-dependent increase in mean arterial blood pressure (EC50=19.5 mg/kg) in the rat. The product is not sterile.

Product Specification

Alternative Name:L-NIO
 
Formula:C7H15N3O2 . HCl
 
MW:209.7
 
CAS:150403-88-6
 
Purity:≥95% (TLC)
 
Identity:Determined by 1H-NMR and MS.
 
Appearance:White to off-white solid.
 
MeltingPoint:220-222°C
 
Solubility:Soluble in water (25mg/ml) or methanol (100mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Handling:Hygroscopic.
 
bml-cn248
Please mouse over
bml-cn248

Product Literature References

Protective effects of inhibitors of nitric oxide synthase in immune complex-induced vasculitis.: M.S. Mulligan et al.; Br. J. Pharmacol. 107, 1159 (1992), Abstract;
Identification of N-iminoethyl-L-ornithine as an irreversible inhibitor of nitric oxide synthase in phagocytic cells.: T.B. McCall et al.; Br. J. Pharmacol. 102, 234 (1991), Abstract;
Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo.: D.D. Rees et al.; Br. J. Pharmacol. 101, 746 (1990), Abstract;
Nitric oxide from L-arginine stimulates the soluble guanylate cyclase in adrenal glands.: M. Palacios et al.; Biochem. Biophys. Res. Commun. 165, 802 (1989), Abstract;
Antimetabolites produced by microorganisms. VI. L-N 5 -(1-iminoethyl) ornithine.: J.P. Scannell et al.; J. Antibiot. (Tokyo) 25, 179 (1972), Abstract;

Product Toolbox

PRODUCT RESOURCES

Datasheet
MSDS
Certificate of Analysis

RELATED PRODUCTS

By target:
NOS
By biological activity:
NOS Inhibitor
By catalog section:

PRODUCT SUPPORT

FAQs
Technical Service
Customer Service

Related Literature

Brochures
Stem Cells
Stem Cells
Download as PDF

All new literature pieces

Recommend this page

 
For Research Use Only. Not for use in diagnostic procedures.
Keep in touch

©2017 Enzo Life Sciences, Inc.,