Replaces Prod. #: ALX-480-026
Cell-permeable, phosphodiesterase-resistant cGMP antagonist. Reversed NO stimulation of random migration in rabbit neutrophils. Used at 30µM to cometively inhibit 8-Br-cGMP relaxation of rabbit aortas. The product is not sterile. Resistant to nucleotide-dependent phosphodiesterases; no metabolic side effects. Significantly more lipophilic and membrane permeant as compared to cyclic GMP or Rp-cGMPS.
Product Details
| Formula: | C10H10BrN5O6PS . Na |
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| MW: | 462.2 |
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| CAS: | 150418-07-8 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White lyophilized powder. |
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| Solubility: | Soluble in water (25mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Cyclic nucleotide phosphodiesterase 1 regulates lysosome-dependent type I collagen protein degradation in vascular smooth muscle cells: Y. Cay, et al.; Arterioscler. Thromb. Vasc. Biol.
31, 616 (2011),
Abstract;
Full Text
Modulation of neutrophil migration by exogenous gaseous nitric oxide: B.E. Van Uffelen, et al.; J. Leukoc. Biol.
60, 94 (1996),
Abstract;
Role of guanylyl cyclase and cGMP-dependent protein kinase in long-term potentiation: M. Zhuo, et al.; Nature
368, 635 (1994),
Abstract;
Rp-8-Br-guanosine-3’,5’-cyclic monophosphorothioate inhibits relaxation elicited by nitroglycerin in rabbit aorta: M. Nakazawa & S. Imai; Eur. J. Pharmacol.
253, 179 (1994),
Abstract;
Nitric oxide regulates luteinizing hormone-releasing hormone secretion: M. Moretto, et al.; Endocrinology
133, 2399 (1993),
Abstract;
