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Rp-8-Br-cGMPS

PKG inhibitor
 
BML-CN216-0500 500 µg 166.00 USD
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Replaces Prod. #: ALX-480-026

Cell-permeable, phosphodiesterase-resistant cGMP antagonist. Reversed NO stimulation of random migration in rabbit neutrophils. Used at 30µM to cometively inhibit 8-Br-cGMP relaxation of rabbit aortas. The product is not sterile. Resistant to nucleotide-dependent phosphodiesterases; no metabolic side effects. Significantly more lipophilic and membrane permeant as compared to cyclic GMP or Rp-cGMPS.

Product Specification

Formula:C10H10BrN5O6PS . Na
 
MW:462.2
 
CAS:150418-07-8
 
Purity:≥98% (HPLC)
 
Appearance:White lyophilized powder.
 
Solubility:Soluble in water (25mg/ml).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
 
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Product Literature References

Cyclic nucleotide phosphodiesterase 1 regulates lysosome-dependent type I collagen protein degradation in vascular smooth muscle cells: Y. Cay, et al.; Arterioscler. Thromb. Vasc. Biol. 31, 616 (2011), Abstract; Full Text
Modulation of neutrophil migration by exogenous gaseous nitric oxide: B.E. Van Uffelen, et al.; J. Leukoc. Biol. 60, 94 (1996), Abstract;
Role of guanylyl cyclase and cGMP-dependent protein kinase in long-term potentiation: M. Zhuo, et al.; Nature 368, 635 (1994), Abstract;
Rp-8-Br-guanosine-3’,5’-cyclic monophosphorothioate inhibits relaxation elicited by nitroglycerin in rabbit aorta: M. Nakazawa & S. Imai; Eur. J. Pharmacol. 253, 179 (1994), Abstract;
Nitric oxide regulates luteinizing hormone-releasing hormone secretion: M. Moretto, et al.; Endocrinology 133, 2399 (1993), Abstract;

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