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Dibutyryl-cGMP

PKG activator
 
BML-CN215-0010 10 mg 98.00 USD
 
BML-CN215-0050 50 mg 385.00 USD
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Replaces Prod. #: ALX-480-046

A cell-permeable cGMP analog which preferentially activates cGMP-dependent protein kinase. Inhibits thrombin stimulated arachidonic acid release in human platelets. Cell permeable.

Product Specification

Formula:C18H23N5O9P . Na
 
MW:484.4 . 23.0
 
CAS:51116-00-8
 
Purity:≥96%
 
Appearance:White solid.
 
Solubility:Soluble in water (100mg/ml). Also soluble in 100% ethanol, DMSO, dimethyl formamide or methanol.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Make solutions fresh daily. Avoid pH >8.5.
 
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Product Literature References

Analysis of the functional role of cGMP-dependent protein kinase in intact human platelets using a specific activator 8-para-chlorophenylthio-cGMP: E. Butt, et al.; Biochem. Pharmacol. 43, 2591 (1992), Abstract;
Cyclic GMP analogs inhibit gamma thrombin-induced arachidonic acid release in human platelets: D.C. Sane, et al.; BBRC 165, 708 (1989), Abstract;
Relaxation of vascular and tracheal smooth muscle by cyclic nucleotide analogs that preferentially activate purified cGMP-dependent protein kinase: S.H. Francis, et al.; Mol. Pharmacol. 34, 506 (1988), Abstract;
’Relaxation of hormonally stimulated smooth muscular tissues by the 8-bromo derivative of cyclic GMP: K.D. Schultz, et al.; Naunyn Schmiedeberg's Arch. Pharmacol. 306, 1 (1979), Abstract;
Analogs of cyclic AMP and cyclic GMP: general methods of synthesis and the relationship of structure to enzymic activity: R.B. Meyer, Jr. & J.P. Miller; Life Sci. 14, 1019 (1974), Abstract;

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